Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 70 for “"Engineering biology"”.
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Design of a robust ratiometric sensor and a long-term memory genetic toggle switch
Synthetic biology is an interdisciplinary field that combines principles of engineering, biology, physics, and others to design and construct novel biological parts, devices, and systems that do not exist in nature. It has the potential to revolutionize many industries, including medicine, …
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Designing for the endless ecosystem
… technologies but extends to materials engineering, biology, and ecology.
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Spore-forming bacteria as pharmaceutical factories
… of current good manufacturing practice, to engineering biology to protect the environment and commercial interests. Bacterial spores have for the past century and a half been known for their dormancy, and it’s about time engineers took advantage.
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Directed evolution of antimutator E. coli
… the nature of the metabolic cost associated with engineering biology and mechanisms by which host adaptation occurs. I also explore cellular pathways involved in genetic stability and examine previously characterized antimutators. Chapter 2 describes the first iteration of a directed evolution …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… field involving in an amalgamation of chemistry, engineering, biology and medicine. In the last part of my study, I have successfully encapsulated DS into polymeric micelle (PM) nanoparticles. The half-life of PM encapsulated DS (PM-DS) was extended to over 3 hours in horse serum. The PM-DS showed …
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Gain-Based Computing for Solving Optimisation Problems
… including, but not limited to, physics, engineering, biology, finance, and machine learning. However, in solving complex optimisation problems, digital computers are increasingly encountering limitations imposed by their traditional von Neumann architecture. This has led to a resurgence …
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Investigation of natural and synthetic coupling of the circadian clock in the cyanobacterium Synechococcus elongatus
… is a well-studied model for microbial chronobiology. However, historical tool limitations have left much still to learn about this clock, including definitive answers as to whether it exhibits coupling. During this PhD project, the tool set has been expanded and subsequently applied to the …
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The internal scattering of ultrasound by biological tissues
… Institute of Technology, Department of Biology, 1976
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Evolution and population genetics of Prochlorococcus marinus
… of Technology, Dept. of Civil and Environmental Engineering, 1995, and Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Elucidating Cell Fate Regulation of the Bone Marrow Vascular Niche Through Development of Engineered Extracellular Matrices
Haematopoietic stem and progenitor cells (HSPCs) are crucial to the curative treatment of a variety of leukaemias and autoimmune diseases. However, their rapid differentiation and exhaustion within 72 hours ex vivo poses a barrier to efficient treatment. Here, we have developed a culture method …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
Harmful algal blooms (HABs) can produce potent neurotoxins that accumulate in seafood and affect human health. One HAB toxin of concern is domoic acid (DomA), a glutamate analog produced by the marine diatom Pseudo-nitzschia spp. Current regulatory limits are designed to prevent acute neurotoxicity …
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Physiological and behavioral responses, and their variability, in squid, Doryteuthis pealeii, embryos and paralarvae reared under chronic ocean acidification
Ocean acidification (OA) and related stressors, like warming, are occurring rapidly in coastal systems. There is concern about the impacts these stressors may have on the early development of species that use the nearshore as nursery habitat. The inshore longfin squid, Doryteuthis pealeii, plays an …
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Characterizing bacterial antibiotic resistance, prevalence, and persistence in the marine environment
Antibiotics are naturally occurring chemicals in bacteria that were recently discovered and utilized by humans. Despite a relatively short time of use, anthropogenic use of antibiotics has increased natural levels of antibiotic resistance, which has caused a looming antibiotic resistance crisis, …
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Self-organized Pattern Formation using Engineered Bacteria
… with inkjet printing technology and metabolic engineering approaches to develop future complex patterned biomaterials.</p>
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Microfuidic Devices and Open Access Tool for Localized Microinjection and Heart Monitoring of Drosophila Melanogaster
This thesis aims to address the current research gaps associated with the use of Drosophila larvae as an in-vivo model for cardiac toxicity and cardiac gene screening. In objective 1, we have developed a hybrid multi-tasking microfluidic platform that enables desired orientation, reversible …
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Optimal bioeconomic management of changing marine resources
Marine populations are increasingly subjected to changing conditions whether through harvest or through broad-scale habitat change. Historically, few models have accounted for such trends over time, and even fewer have been used to study how trends affect optimal harvests. I developed and analyzed …
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