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Showing 1 to 8 of 8 for “"Engineered skeletal muscle"”.
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Cryopreservation of tissue engineered skeletal muscle
Tissue engineered skeletal muscle plays an important role not only in the field of regenerative medicine, but also in emerging areas such as soft robotics, organ-on-a-chip models of disease, and drug testing. However, further expansion of the applications of tissue engineered skeletal muscle models …
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Enhancing the functionality and applicability of engineered skeletal muscle tissue
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Characterizing Engineered Skeletal Muscle Rings as Actuators Using Strain Sensing Methods
… to characterize a force exertion model of engineered skeletal muscle rings. The instrument uses strain gauges to transduce a muscle ring contraction and has a verified resolution of 5 μN and 1.4 μm over the ranges of 5 μN and 1400 μm respectively. Experiments were carried out with four …
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Enhancing functionalities of engineered skeletal muscle tissues by recreating natural environmental cues
Engineered skeletal muscle tissue is a three-dimensional contractile tissue made from muscle cells and the extracellular matrix (ECM). It can be used as a drug testing platform or an implantable tissue, but its practical use has been limited by inferior contractile performance and small size …
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DEVELOPMENT OF A TISSUE ENGINEERED SKELETAL MUSCLE REPAIR CONSTRUCT FEATURING BIOMIMETIC PHYSICAL, CHEMICAL, AND MECHANICAL CUES
Volumetric muscle loss (VML) injuries are particularly debilitating, and commonly result from trauma, infection, congenital defect, or surgical side effect. Unfortunately, current medical treatments for these injuries are lacking. The "gold standard" for treatment of critical-size defects remains …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
<p>Tissue-engineered skeletal muscle presents promising opportunities for developing high-fidelity in vitro models for investigating human muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite cells (SCs) are essential for new muscle fiber formation; however, …
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Manipulating Stiffness of Biomechanical Systems to Train Muscle
… robots, millimeter scale soft robots powered by engineered muscle actuators, was developed to provide a binary change in stiffness. Two variations of the design were created, one using elastic 50A resin and the other PDMS. The elastic 50A resin design was fabricated successfully. The design uses …
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Positioning Microtissues on the Differentiation Continuum Reveals their Utility for Studying Skeletal Myopathies and Metabolic Disease
Insulin resistance in skeletal muscle is the primary defect in type 2 diabetes (T2D). While current in vitro models utilize two-dimensional (2D) myotubes, these cultures express low levels of insulin-responsive GLUT4 and elevated levels of insulin-independent GLUT1, limiting their relevance for …