Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Engineered Heart Tissues"”.
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Engineered Heart Tissues for Advanced Disease Modeling
… three-dimensional environment to generate engineered heart tissues (EHTs). The EHT platform matures hiPSC-CMs by providing the environmental cues present in the in vivo myocardium while allowing for assessments of cardiac function. Although heart failure is the leading cause of death in …
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Cellular therapy for chronic heart failure: a key role for epicardial fibronectin
… cardiomyocyte loss, frequently leading to heart failure, with a 50% 5-year mortality. At subacute time points following MI, animal studies have shown ‘remuscularization’ of the damaged heart with human embryonic stem cell (hESC)-derived cardiomyocytes. Recently, outcomes were improved by …
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Interactions of Cardiomyocytes and Myofibroblasts: An Experimental and Theoretical Model Study
… hypertension or infarction, fibroblasts in the heart can convert to myofibroblasts, a larger and more contractile phenotype between a fibroblast and a smooth muscle cell. Myofibroblasts are essential to wound healing, but can change the compliance and functioning of heart tissue and can produce …
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Investigating the role of the cardiac apelin receptor using human embryonic stem cell derived-cardiomyocytes.
… the apelin receptor at similar levels to human hearts, indicating suitability for use as a model for investigating the apelin receptor. A novel apelin receptor inducible knockdown system was generated in hESCs. Inducing apelin receptor knockdown throughout differentiation reduced cardiomyocyte …