Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Energy Stress"”.
-
Energy Stress Causes Chaperones to Assemble Into Cytoplasmic Complexes
… into tertiary and quaternary structures. Certain stresses can compromise the weak hydrophobic forces responsible for these structures and lead to protein unfolding, misfolding, and aggregation. Aggregates of proteins are hallmarks of devastating diseases such as Alzheimer’s, Parkinson’s, and …
-
Lkb1 Deficient Non-Small Cell Lung Cancer Cells Are Vulnerable to Energy Stress Induced By Atp Depletion
… <p>In normal cells, LKB1 regulates cellular energy by balancing energy production and consumption. Because tumor cells need vast amounts of energy for their growth, they must adapt alternative strategies to amplify their energy production. During low energy condition in normal cells, LKB1 …
-
Response of cool-season turfgrass to foliar applied and stabilized nitrogen fertilizers
… sources lead to enhanced turf performance under energy stress. A further objective was to assess whether stabilized N fertilizers offered a benefit over unamended sources under field conditions. Experiments to address these objectives were carried out at the Landscape Horticulture Research Center …
-
Understanding The Role of Sumoylation In Regulating Lkb1 Function
<p>Energy homeostasis in a cell is critical for its survival during metabolic stress. Liver kinase B1 (LKB1), one of the key regulators of cellular energy balance, was initially discovered as a tumor suppressor mutated in patients with Peutz-Jeghers syndrome. Germline mutations in LKB1 predispose …
-
Novel Posttranslational Modification In Lkb1 Activation and Function
… provides a survival advantage for cells under energy stress. LKB1 forms a heterotrimeric complex and is activated through binding of the two regulatory proteins, STRAD and MO25. LKB1 has been shown to be a tumor-suppressor in various mouse models; however, recent studies suggest that LKB1 has …
-
Disclinations in Homogeneously Deformed Nematic Elastomers
… a markedly different distribution for the free energy, deformational stress, and pressure than the isotropic region. This distribution of energy, stress and pressure determines the radius of the core to be on the order of 10-2 mum. The constitutively determined contribution to the orientational …
-
Anoxia-Induced Changes in Action Potential Propagation in a Non-Myelinated Axon
… of the system to survive disturbances caused by stress. While some organisms compensate for extreme changes in the abiotic features of their environment, the mechanisms underlying this are poorly understood. We used the locust Descending Contralateral Movement Detector (DCMD) neuron to study how …
-
Mathematical and Computational Modeling of Injection-induced Seismicity
… hazard and environmental impact of subsurface energy technologies. Understanding the physical mechanisms that lead to induced seismicity is essential in efforts to mitigate the risk associated with subsurface operations. As a first step in this thesis, we develop a spring-poroslider model of …
-
Canonical and non-canonical regulation of AMP-activated protein kinase
… protein kinase (AMPK) is a sensor of cellular energy stress that, once activated, promotes ATP-producing process while it switches off ATP-consuming pathways, in order to restore the cellular energetic balance under conditions of stress. Activation of AMPK is dependent on the phosphorylation of …
-
Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
The AMP-activated protein kinase (AMPK) is an energy sensor that maintains cellular metabolic homeostasis in a cell-autonomous manner during energy stress conditions, such as hypoxia and glucose deprivation. Emerging evidence suggests that AMPK activation during metabolic stress conditions may have …
-
Die Rolle der beiden Transkriptionsfaktoren AtbZIP1 und AtbZIP53 aus Arabidopsis thaliana in der Anpassung des pflanzlichen Metabolismus an Energiemangelbedingungen
Energiemangelbedingungen, wie sie während langanhaltender Dunkelheit auftreten, führen zu einer massiven Umprogrammierung des pflanzlichen Metabolismus. Dies hat den Abbau von Proteinen, Aminosäuren und Nukleinsäuren sowie die Hydrolyse von Polysacchariden und Oxidation von Fettsäuren zur Folge, …
-
The Arabidopsis C/S1 bacic leucine Zipper transcription factor network:Impact of heterodimer formation on target gene transcription
… während der Rehydrierung nach osmotischem Stress. Die ProDH ist ein direktes Zielgen des Gruppe S1 bZIP TF AtbZIP53. In den Dimerisierungsstudien wurde eine synergistische Erhöhung der Aktivität des Zielgens mit Hilfe des Gruppe C-Faktors AtbZIP10 gezeigt. Dieses Heterodimer-induzierte …
-
Molecular Dynamics Simulation of Forsterite and Magnesite Mechanical Properties: Effect of Carbonation on Comminution Energy
… reduction of rock and subsequently comminution energy during the crushing and processing of the ore. We investigated how these materials respond to different physical conditions, such as temperature and strain rate, to understand their behavior under stress. By examining the molecular structure …