Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Enediyne"”.
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Spontaneity to serendipity: from an enediyne core biosynthetic hypothesis to the hexadehydro-Diels-Alder reaction
Enediyne containing natural products have promising potential as cancer therapeutics due to their unique molecular architecture. The (Z)-1,5-diyn-3-ene subunit in the enediyne core can undergo cycloaromatization to yield a diradical capable of scission of the DNA double helix. While the biological …
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The selection of DNA damage targets in vivo and in vitro by enediyne antitumor antibiotics
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1998.
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Enediynylacridans: design and synthesis of oxidase triggered diyl progenitors
… via 1,4- benzenoid diradicals of enediyne systems. Since 1985, five enediyne fungal products with anticancer antibiotic activity have been structurally elucidated, namely, neocarzinostatin chromophore, the calicheamicins, the esperamicins, the dynemicins, and kedarcidin …
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Radical cyclization approach to a chemoenzymatic synthesis of morphine
… compound. See: Figure 4 The silicon-tethered enediyne [figure 4] was prepared as a model for use in the well-known Bergman cyclization reaction as a "latent benzene reagent". Bergman cycloaromatization of similar enediynes has been demonstrated and the cyclization temperatures to form the …
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Structure Determination of Natural Product Biosynthesis Enzymes
Natural products (NPs) frequently display elaborate molecular frameworks challenging biologists to ascertain the genetic origin and catalytic logic affording intricate NP biosynthesis. Beyond the basic research inspired by multiplicity of NPs discovered thus far, the biological activities …
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A. Discovery of novel reactivity under the Sonogashira reaction conditions B. Synthesis of functionalized BODIPYs and BODIPY-sugar conjugates
A. During our attempts to synthesize substituted enediynes, coupling reactions between terminal alkynes and 1,2-cis-dihaloalkenes under the Sonogashira reaction conditions failed to give the corresponding substituted enediynes. Under these conditions, terminal alkynes underwent self-trimerization …