Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Ene Reaction"”.
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Diazetines, diazetidines, and mechanisms of the ene reaction
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1982.
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DEVELOPMENT OF METAL-CATALYZED REACTIONS OF ALLENES WITH IMINES AND THE INVESTIGATION OF BRΘNSTED ACID CATALYZED ENE REACTIONS
… century, scientists have been discovering new reactions to generate interesting synthetic targets. As these new reactions have emerged, they are constantly tweaked so that an array of substrates can be synthesized and better catalysts can be discovered. The focus of our research is to two-fold: …
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Pericyclic reactions in organic synthesis
… processes. An intramolecular propargylic ene reaction of a 1,6-diyne is used to generate a vinylallene, which then reacts in an inter- or intramolecular Diels-Alder reaction with an alkenyl or alkynyl dienophile. Reactions involving unsymmetrical alkenyl and alkynyl dienophiles proceed …
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New C 1- and C 2-symmetric sulfoximines : synthesis and application in enantioselective metal catalysis
… in the Cu-catalyzed Mukaiyama-aldol reaction, modifications of this class of potential ligand by substitution of the aryl bridge was effected. Gratifyingly, a methyl-substituted aminosulfoximine proved to be the best ligand of our screening in the Cu-catalyzed carbonyl-ene reaction …
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Tandem benzannulation-ring closing metathesis strategy for the synthesis of benzo-fused nitrogen heterocycles ;
… This strategy is based on the benzannulation reaction of ynamides with cyclobutenones or [alpha]-diazo ketones to generate highly-substituted aniline derivatives, which then participate in ring-closing metathesis reactions to form nitrogen heterocycles. The synthetic utility of this strategy …
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Investigation of the synthesis and thermal rearrangements of 1,2,3,4,5-Pentaphenyl-2,4,-Cyclopentadiene Alkyl Ethers
… of six 1,2,3,4,5-pentaphenyl-2,4-cyclopentadiene alkyl ethers was investigated. It was determined that the most efficient route to these ethers was not the most generally accepted route to ethers - the Williamson Reaction - but rather a solvolysis reaction between …
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Nickel-catalyzed reductive coupling reactions of 1,6-enynes and the total synthesis of (+)-acutiphycin
Nickel-Catalyzed Reductive Coupling Reactions of Aldehydes and Chiral 1,6-Enynes. A study of nickel-catalyzed reductive coupling reactions of aldehydes and chiral 1,6-enynes has provided evidence for stereospecific ligand substitution from a planar three-coordinate nickel species as a plausible …
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Nucleophilic Carbon-Carbon Bond-Forming Reactions of 2-Methylenetetrahydropyrans
<p>Reactions with 2-methylenetetrahydropyrans are underutilized in the literature, especially with respect to general methods demonstrating their nucleophilic nature. This work provides three general methods toward the synthesis of 2-β-oxygenated pyranyl substrates, which are key structural …
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Catalytic one-carbon homologation of alkenes
… broadly applicable methods for homologating alkenes remains an unmet synthetic need. This thesis describes the development of a catalytic, one-pot method for the one-carbon homologation of alkenes. The methodology leverages the intrinsic reactivity of an allyl sulfone reagent, which undergoes …
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Experimental and Computational Studies on Copper and Hydrobenzoin Derivatives in Catalytic Asymmetric Reactions
… understand a copper promoted amino oxygenation reaction reported by Chemler et al. Using Density Functional Theory (DFT), employing the hybrid B3LYP functional and a LanL2DZ/6-31G(d) basis set, the mechanistic details were studied on a N-tosyl-o-allylaniline and a [alpha]-methyl-[gamma]-alkenyl …
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Studies towards the synthesis of the guaianolide and pseudoguaianolide skeleton
… and pseudoguaianolides are sesquiterpene lactones and share a sommon backbone: the guaiane skeleton. Hundreds of natural products belong to these families of compounds. The guaiane skeleton is characterised by a bicyclo[5.3.0]decane ring system (perhydroazulene). Among the guaianolide …
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Peptide/Protein Stapling and Unstapling: Introduction and Photorelease of Isobutylene Graft
… strategy with an isobutylene graft. The reaction is mild and proceeds rapidly and efficiently both with linear and cyclic peptide substrates. The resulting isobutylene-grafted peptides possess improved passive membrane permeability, and are stable in human plasma and in the …
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Tailoring Siloxane Functionality for Lithography-based 3D Printing
… polyethers for emerging applications. The thiol-ene reaction possesses many desirable traits for vat photopolymerization (VP) AM, namely that it proceeds rapidly to high yield, does not undergo significant side reactions, remains tolerant of the presence of water or oxygen, and remains …
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En-Reaktion von Nitrosoaren, Triazolindion und Singulettsauerstoff
… (1O2) durch Bestimmung von kinetischen Isotopeneffekten, Regioselektivitäten und Diastereoselektivitäten mit ausgewählten, deuteriummarkierten Olefinsubstraten untersucht, wobei das Hauptaugenmerk auf dem Nitrosoaren-Enophil 4-Nitronitrosobenzol lag. Ferner wurden diese En-Reaktionen mit …
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Mechanistic, Biochemical, and Theoretical Studies of Phototoxicity and Photobluing
… for a previously unexplored 4-carbon truncation reaction that converts the simplest heptamethine cyanine to the corresponding trimethine cyanine. We propose a DFT-supported model describing a singlet oxygen (<sup>1</sup>O<sub>2</sub>) mediated formation of an allene hydroperoxide intermediate and …