Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Endotype"”.
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Endotype Discovery in Acute Respiratory Distress Syndrome
Endotype Discovery in Acute Respiratory Distress Syndrome Dr Romit Samanta Acute respiratory distress syndrome (ARDS) affects 10% of critical care patients and is characterised by acute refractory hypoxaemia and bilateral pulmonary infiltrates on thoracic imaging. Mortality from severe ARDS is …
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Identifying a Glucocorticoid-activated GPCR that Rapidly and Non-Genomically Increases cAMP Levels in Mammalian Cells
… and/or the presence of a neutrophilic endotype. One understudied phenomenon of GCs is their ability to induce rapid, non-genomic actions. For example, GCs can acutely modulate calcium concentrations levels, induce smooth muscle relaxation and modulate nitric oxide synthase activity, …
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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa
… in the skin and blood, suggesting a novel HS endotype. Data from our clinical trial of brodalumab, a human anti-IL-17 receptor A (IL-17RA) monoclonal antibody, provides the first molecular characterization of IL-17 pathway blockade in HS. We demonstrate that treatment with brodalumab reduces …
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Genomic and metabolomic interrogation of body composition and insulin resistance endotypes
… lipid panels provided some of the cleanest endotype discrimination in both cohorts (Cambridge: 178-metabolite consensus set; ARI = 0.952; SS = 0.231; 1 misclassification; NIH: 171-metabolite consensus set; ARI = 0.804; SS = 0.286; 3 misclassifications), supporting a prominent neutral-lipid …