Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Endothelium, Vascular"”.
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Investigating Vascular Patterning and Regression in Kidney Development and Organoids
Pages 74-127 are misnumbered as pages 75-128.
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Histone Deacetylase 7 and Transcriptional Regulatory Networks of the Vascular Endothelium
… on HDAC7, a class II HDAC that is expressed in vascular endothelial cells and whose function is essential for the maintenance of vascular integrity during embryogenesis. Mice lacking HDAC7 die by e11.5 with complex cardiovascular malformations including endothelial, vascular smooth muscle, and …
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Blood Vessel Development
Cardiovascular system is the first developing functional organ in vertebrates, and one of the fundamental organ systems through adulthoods. Cardiovascular function depends on patent blood vessel formation by endothelial cells. In this dissertation, a careful analysis of different aspects of blood …
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Identifying Depression Utilizing Tumor Necrosis Factor–[alpha] and Endothelial Function in Spinal Cord Injury
People with spinal cord injury (SCI) are at high risk of developing pressure injuries (PrI) and depression. Depression has been shown to be associated with increased risk for PrI complications, and it is suggested that physiological changes related to depression may contribute to PrI development. …
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Cocaine Induces Apoptosis in Coronary Artery Endothelial Cells: Cellular and Molecular Mechanisms
… abuse has been associated with numerous cardiovascular consequences, such as depressed myocardial contractility, elevated blood pressure, coronary artery vasoconstriction, and myocardial ischemia and infarction. The multifactorial effects of cocaine often contribute to its sympathomimetic …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… promote gene transcription of ligands such as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is sustained. Results suggest that …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic brain injury, myocardial ischemia, diabetes, and developmental anomalies. With this remodeling comes changes in vessel …
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VEGF and Sympathetic Perivascular Nerves Contribute to Hypoxic Remodeling of Ovine Cranial Arteries
… pathologies that include compromised fetal cardiovascular structure and function. Mechanisms involved remain unclear. Because hypoxia increases production of VEGF, known to modulate smooth muscle (SM) phenotype, this thesis explored the hypothesis that VEGF contributes to hypoxic fetal vascular …
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Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
Heart disease remains the leading cause of death worldwide. As a result of studies done by Barker and associates, our awareness of the significance of stress during gestation as a risk factor for heart diseases has expanded. We now know that events in utero can significantly alter gene expression …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
… in the expression level of caveolin-1 in the endothelium and reactive astrocytes following juvenile TBI. Furthermore, acute administration of cavtratin, a peptide mimetic of caveolin-1 scaffolding domain, markedly reduced edema formation and lesion volume without improving sensorimotor outcome …