Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Endothelin-1(ET-1)"”.
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P27 Expression in Endothelin-1 Stimulated Mitogenesis
… have been shown in our lab to synthesize and secrete endothelin-1 (ET-1). The endothelin-1 binds ETA receptors, this elevates intracellular calcium, stimulate DNA replication and cell division. This investigation explores ET-l's role as a mitogenic factor in corneal endothelial cells and addresses …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia Inducible Factor-1α (HIF- 1α), which complexes with HIF-1β to form the active HIF-1 dimer that …
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Studies of the mammalian ovarian endothelin system
In porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
… respectively, in cardiomyocytes. We sought to determine the direct interaction between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin. The adipose tissue conditioned medium (ACM) inhibited the …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
… phosphorylation in this process is unknown. Endothelin-1 (ET-1; 1-100nM, 2-30min) and other hypertrophic factors induced a time- and dose-dependent increase in FAK-S910 phosphorylation in neonatal rat ventricular myocytes (NRVM). FAK-S910 phosphorylation required ET<sub>A</sub>R-dependent …
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Expansion of neural stem cells as a treatment for ischemic stroke
Adulte Neurogenese in Säugetieren ist eingeschränkt auf zwei Gehirnbereiche, der subgranulären Zone (SGZ) des Hippocampus und der subventrikulären Zone (SVZ) um die Ventrikelwände herum. Vorhergehende Arbeiten in unserem Labor haben gezeigt, dass Überexpression der Zellzyklusregulatoren Cdk4/Ccnd1 …
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Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… pain, there is still concern regarding the safety of using analgesics and anesthetics in infants. This thesis has developed an animal model using Endothelin-1 (ET-1), a peptide that is involved in vaso-occlusive crisis, to investigate the cellular and molecule mechanisms by which painful VOEs …
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Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
<p>The purpose of this study was to determine whether Endothelin-1 (ET-1) induced cellular responses in bovine corneal endothelial cells (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent …
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The Effect of Endothelin-1 on the expression of CDK Inhibitors p21 & p27 in Bovine Corneal Endothelial Cells
… cell cycle. The purpose of this study was to determine whether the down regulation of cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal …
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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
… results of intercellular communication between melanocytes and keratinocytes for each of these cell types. I characterized the transcriptomes of human melanocytes and keratinocytes that were freshly derived from human tissue in Chapter 2. These data served as a reference for comparison …
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Prostaglandin-Mediated Reinstatement of Drug Taking After Alcohol Drinking by Female Adolescent Rats
… adolescence is associated with subsequent Meth dependence in humans. Specifically, female adolescents are particularly vulnerable to serial alcohol and Meth use. However, it is unknown if prior voluntary alcohol drinking impacts subsequent Meth-taking in female adolescent rats. Both alcohol …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… of premigratory neural crest cells or targeted deletion of genes required for their proliferation, migration or survival. However, the transcription factors and signaling molecules that specify unique subsets of neural crest cells are still being detailed. This thesis represents efforts to …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… of premigratory neural crest cells or targeted deletion of genes required for their proliferation, migration or survival. However, the transcription factors and signaling molecules that specify unique subsets of neural crest cells are still being detailed. This thesis represents efforts to …
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Children Active To Stay Healthy (CASH): Exercise as a Tool for Reducing Inflammation and Cardiovascular Risk in Sedentary, Pubescent Adolescents With Obesity
… aerobic capacity, blood lipids, glucose metabolism, endothelial function, and inflammation were measured pre- and post-intervention. 27 (17 females and 10 males; mean age 14.7 ± 1.5 years) completed the exercise intervention. A significant decrease in waist-to-hip ratio was detected in …
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Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
A variety of neurologic illnesses including peripheral and cranial neuropathies, central vestibular disease, seizures and coma have been associated with hypothyroidism in dogs. Repeated studies have shown that there is loss of blood brain barrier (BBB) integrity in these animals. Current research …
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… mediators in the kidney. Myoglobin stimulated endothelin-1 (ET-1) production in proximal tubular cells, an effect driven by NADPH oxidase-dependent oxyradical generation. Rats subjected to glycerol-induced rhabdomyolysis also exhibited ROS-dependent ET-1 production. Vasoactive ET-1 is generated …
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Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… Recent evidences suggest that factors secreted by activated astrocytes might contribute to degeneration of MNs. We focused on endothelin-1 (ET-1), a peptide which is strongly up-regulated in reactive astrocytes under different pathological conditions. We show that ET-1 is abundantly …
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The Study of Serial Histochemical Changes in Laser-related Post-inflammatory Hyperpigmentation
… showed that melanin pigment was removed and detected on the corneal layer as extracellular melanin. At day 28, either hyperpigmentation or hypopigmentation was observed, while interestingly, no definite alteration was seen in the subject treated with corticosteroid. Immunohistochemical …
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Mitochondrial Regulation of Arterial Contractility
… cerebral arteries.</p> <p><strong>Methods and Results:</strong> Endothelin–1 (ET–1) activated Ca<sup>2+</sup> waves and elevated global Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) via inositol 1,4,5–triphosphate receptor (IP<sub>3</sub>R) activation. …
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Investigating causal biologic mechanisms involved in differential serum bone-specific alkaline phosphatase activities in canine appendicular osteosarcoma
Made available in DSpace on 2015-07-22T22:16:04Z (GMT). No. of bitstreams: 3 Neumann_Zachary12.pdf: 2342749 bytes, checksum: de57a780726f8c529c3849886e2b3b9f (MD5) Neumann_Zachary.docx: 5408475 bytes, checksum: 8de997d0535e23ec673946a7983c65df (MD5) license.txt: 4065 bytes, checksum: …
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