Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Endothelin receptor"”.
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Investigating endothelin receptor B signalling during myelination
… including those mediated by G protein‐coupled receptor (GPR) superfamily members. One GPR, Endothelin receptor B (EDNRB), best known for regulating blood flow, had previously been demonstrated to both positively and negatively influence myelination. I have investigated how EDNRB regulates …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating …
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Portal hypertension in cirrhosis and its associated pulmonary vascular disorders
… in the chronic setting, are limited to β-adrenoreceptor blockers, with many patients failing to respond. There is a current unmet need to identify new therapeutic targets for drug treatments. This research aimed to identify novel clinical and biochemical markers for patients with PoPH and HPS in …
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The role of endothelin-2 in ovulation
… maintenance. Just prior to ovulation, the gene endothelin-2 (Edn2) is highly yet transiently expressed for a two-hour window. Mature endothelin-2 protein (EDN2) is a 21 amino acid peptide that is classically described as a potent vasoconstrictor. EDN2 is produced exclusively by the granulosa …
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An <i>in vitro</i> human 3D co-culture model to study endothelial-astrocyte interactions
… acidic protein (GF AP), aquaporin-4 (AQP4), endothelin-l (Et-l) and endothelin receptor type-B (EDNRB), were compared between 3D and 2D cultured HA. The decreased expression of AQP4 and EDNRB and the much-decreased proliferation rate of 3D HA suggested their reduced reactivity and a …
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Angiogenesis and angioregression gene expression analyses in swine corpus luteum
… CL formation and luteolysis is the isopeptide Endothelin-1 (ET-1), which is well-known to be a potent vasoconstrictor and mitogen for endothelial cells. The goal of the present thesis was to study the role and regulation of vascularisation in an adult vascular bed. For this purpose, using a …
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Μελέτη του ρόλου της ενδοθηλίνης και των υποδοχέων της στην επιθηλιομεσεγχυματική μετατροπή στο αδενοκαρκίνωμα του προστάτη
Η επιθήλιο-μεσεγχυματική μετατροπή (ΕΜΤ) αποτελεί ένα φυσιολογικό μηχανισμό που ενεργοποιείται κατά την εμβρυογένεση και την επούλωση τραυμάτων. Είναι ένας μοριακός μηχανισμός που συμβάλει στην μετατροπή των επιθηλιακών κυττάρων σε μεσεγχυματικά, προσδίδοντας τους χαρακτηριστικά όπως αυξημένη …