Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Endothelialization"”.
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Endothelialization of Bypass Grafts Using Autologous Stem Cells
… availability of autologous vessel grafts. Endothelialization of luminal grafts can be done through pre-seeding with non-thrombogenic cells. Adipose-derived mesenchymal stem cells (ASCs) are good source of autologous stem cells for vascular differentiation, especially endothelial cells …
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Isolating and optimising transmural endothelialization as an independent mode of spontaneous vascular graft healing
… to exclusively investigate transanastomotic endothelialization(TAE), which is known to be limited to the perianastomotic region in humans. Alternative spontaneous forms of endothelialization (fallout and transmural) need to be independently investigated and optimised to redirect future …
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In vitro endothelialization of vascular prostheses: a possible means to improve the early patency of small diameter vascular grafts
In contrast to other mammalians spontaneous endothelialization does not occur in humans. Since this lack of a functioning endothelium is thought to be a main reason for the unsatisfying performance of synthetic arterial grafts, we attempted to create an endothelium on the prosthetic surface by …
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Development of Multilayer Vascular Grafts Based on Collagen-Mimetic Hydrogels
… modulus to offer unique control over graft endothelialization. However, scaffold properties that promote endothelialization may not be consistent with the mechanical properties necessary to withstand physiological loading. To address this issue, we have reinforced PEG-Scl2-2 hydrogels with …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
BACKGROUND: Poor endothelialization and intimal hyperplasia are major causes of small diameter vascular conduit (SDVC) failure. The present study was aimed to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. …
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Die Auswirkungen vom 188-Rhenium-Stents auf Neointimadicke, Stenosegrad und histologische Parameter in der Gefäßwand im Schafmodell
… area stenosis and the histological parameter endothelialization, oedema, apoptosis, inflammation, thrombosis and the grade of smooth muscle cells in the neointima. We implantated thirty stents, 15 of which were radioactive (mean activity 21,02 MBq) and 15 of which were non-radioactive (control …
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Design and nondestructive imaging of a bioengineered vascular graft endothelium
… used to noninvasively quantify vascular graft endothelialization, EC detachment, and apoptosis through the vessel wall with greater imaging penetration depth than two-photon microscopy. Additionally, the FOB method was capable of continuously tracking EC migration and endothelialization of a …
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Regulatory Mechanisms Underlying the Differentiation of Mesenchymal Stem Cells to Endothelial Cells
… endothelial injury. However, re-endothelialization by VEGF-induced BM-derived MSCs remains a complex clinical challenge. Following intracoronary or transendocardial delivery of the BM-derived MSCs, only ~10% of the differentiating cells engraft, and the majority of those persist …
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In Vitro and In Silico Study of Deposition on Textured Biomaterials: Towards Biofunctionalization of Ventricular Cannula
… solution for hemocompatible materials. To induce endothelialization and improve hemocompatibility, LVAD manufacturers adopted powder sintering in multiple contemporary LVADs. Despite the wide adoption of sintered titanium, clinical outcomes over the past several decades have been highly variable, …
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CD133 Antibody Conjugation to Decellularized Human Heart Valves For Circulating Endothelial Progenitor Cell Capture
… functionalized surfaces capable of rapid in vivo endothelialization have been developed. The aim of this study is to examine the capacity of CD133 antibody-conjugated valve tissue to capture circulating endothelial progenitor cells (EPCs). Decellularized human pulmonary valve tissue was conjugated …
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Improving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers
… alternative. The third aim examines endothelialization and smooth muscle cell (SMC) modulation on TAN-CMKC-modified TiNT. These modifications enhanced endothelial cell adhesion, proliferation, and migration while significantly suppressing SMC proliferation and migration, critical for …
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A study of nanostructured materials toward coronary artery stenting and DNA-based biosensing
… confirmed the coatings promoted suitable endothelialization while minimizing the potential fr thrombosis. Surface chemical and electrochemical studies showed that nanocoating chemical groups remained stable under dry storage (25 [degrees]C) and in a simulated body fluid at 37 [degrees]C …
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Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
… into solvent selection, uniformity of HA, endothelialization, and dynamic flow testing would be beneficial in the evaluation of these materials for use in small diameter vascular graft bypass procedures.
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… remain problematic, in part due to limited re-endothelialization. Thus, DESs coated with drugs targeting specifically synthetic VSMCs, but not the endothelium, might limit these problems. Since the cyclic nucleotide phosphodiesterase, PDE1C, a dual cAMP/cGMP hydrolyzing PDE, is exclusively …
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Development of a tissue-regenerative vascular graft: Structural and Mechanical Aspects
… scaffolds as promising solution for the lack of endothelialization seen in the small-calibre synthetic vascular graft. Another cause of graft failure was reported to be the mechanical mismatch between the graft and the host vessel. This study concerned the investigation and optimization of …
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Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
… Chapter 6 artificially stimulates P-selectin endothelialization in quiescent endothelium to improve BMC engraftment rates even after endogenous activation subsides. Low-dose peroxide, a reactive oxygen species known to induce brief inflammation, when delivered prior to BMC infusion, enhances …
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Geometry induced flow disturbances
… that alleviate thrombus formation and promote endothelialization. The first study employed time-resolved Digital Particle Image Velocimetry (DPIV) to compare the hemodynamic performance of two stents in a compliant vessel. The first stent was a rigid insert, representing an extreme compliance …
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