Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Endothelial permeability"”.
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
… in the juvenile brain. To this end, the endothelial caveolins and c-Jun N-terminal kinases (JNKs) were identified as proteins of interest in the regulation of brain endothelial permeability after injury. These were investigated under a three-fold aim. The first was to characterize the …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… pathways that regulate the integrity of inter endothelial junctions in response to mechanical perturbations. The vascular endothelium forms a natural barrier between blood and tissues and its disruption leads to blood leakage and serious pathological consequences. VE-cadherin—the primary …
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Role of Sodium Arsenite in Atherogenesis
… C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in atherosclerotic …
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Role of Sodium Arsenite in Atherogenesis
… C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in atherosclerotic …
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… cell motility combined with quantitation of the endothelial barrier function. Compared with traditional in vitro assays, microfluidic assays enable "user-defined" design of the cellular and acellular microenvironment with spatio-temporal control and live high-resolution imaging. Formation of …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… endothelium leading to increased microvascular permeability, the mechanisms of which are completely unknown. We sought to determine the impact of host responses to infection on increasing microvascular permeability both in vitro and in vivo. Our work has revealed a role for TNF-á, IL-1â, and …
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The Role of Arginine Vasopressin Receptor 2 in Microvascular Hyperpermeability During Severe Sepsis and Septic Shock
… that V2R activation induces vascular hyperpermeability. The hypothesis was tested using a well-characterized ovine model of MRSA sepsis and various in vitro cell-based assays with human lung microvascular endothelial cells (HMVECs). Results demonstrated that the treatment of septic sheep …
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Shear Stress-Mediated Tumor-Endothelial Cross Talk Regulates the Angiogenic Potential of Breast Tumors In Vitro
… the reciprocal interaction between tumor and endothelial cells to mediate angiogenesis, and the role of flow shear stress on this process, may offer insight into the design of improved therapeutic strategies to control vascularized tumors. Instrumental to this is the development of …
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… reorganisation, cellular contractility and endothelial permeability. Eventually, the loss of the tightly-organised monolayer integrity of the endothelium results in blood vessel disruption and intratumoral haemorrhages. The tubulin-binding agents discussed in this thesis are derived from the …
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Angiogenesis and angioregression gene expression analyses in swine corpus luteum
… in the body with a proliferation rate of the endothelial cells 4- to 20-fold more intense than in some of the most malignant human tumours. This angiogenic process should be rigorously controlled to allow the repeated opportunities of fertilization. After a first period of rapid growth, the …