Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Endothelial activation"”.
-
A study of platelets and the endothelium in idiopathic pulmonary fibrosis
… experiments: (1) investigation of the platelet endothelial cell adhesion molecule-1 single nucleotide polymorphisms in IPF and controls; (2) assessment of markers of platelet activation in IPF and controls; (3) investigation of the effect of IPF plasma on control platelets; (4) assessment of …
-
Vascular and metabolic profile of 5-year sustained hypertensive versus normotensive black South Africans
… higher pressure load on the brain. Inflammation, endothelial activation, dyslipidemia, hyperglycemia and health behaviours may also influence hypertension and arterial stiffness. Limited information is availiable on these associations in black South Africans. The high prevalence of hypertension …
-
Insights into the mechanisms of wound repair and the role of TP508 in tissue regeneration
… phosphatase PTP-PEST as a potential regulator of endothelial adherens junctions and the tissue repair peptide TP508 as a potential modulator of inflammatory-induced endothelial activation. Second, these experiments aimed to determine how TP508 promoted dermal wound healing using two models of …
-
Effect of Carbon Monoxide-Releasing Molecule-3 on the Severity of Endothelial Dysfunction Due to Elevation of Hydrostatic Pressure in an In Vitro Model of Compartment Syndrome
… and structural changes within the human vascular endothelial cells; application of CORM-3 diminished the magnitude of these detrimental responses. The data suggest that CORM-3 provides beneficial effects by preventing endothelial activation while preserving endothelial integrity, making CORM-3 an …
-
Value of Raisins for Reduction of Oxidative Stress, Endothelial Dysfunction, and Inflammation in Obesity
… on markers of inflammation, oxidative stress and endothelial activation in response to an acute high-fat meal in obese individuals. Seventeen overweight men and women consumed raisins or placebo (264 kcal/d) for 14 d in a randomized cross-over design while following a low-flavonoid, …
-
Clinical and epidemiologic aspects of Rheumatoid Arthritis. Special emphasis on cardiovascular outcome and risk factors
… study markers of inflammation in vascular endothelial cells during treatment with a TNF-inhibitor. We also investigated predictors of RA. Two community based of RA cohorts were established in 1978 and 1995 and compared to the corresponding background population regarding CVD. Patients were …
-
HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
… One mechanism for this pathology may involve endothelial activation either by HIV itself or by its secreted proteins, gp120 (a viral envelope protein) and tat (a protein that upregulates transcription of viral genes). We have studied the effects of gp120 and tat on signaling and production of …
-
Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
… falciparum were found to be partially coupled. Activation of Toll-like receptors (TLRs) by purified parasite components increased internalization of parasitized erythrocytes, but uptake of parasitized erythrocytes did not require TLRs, nor did it trigger cytokine production via TLRs or other …
-
Intracellular sphingosine kinase activity as a regulator of endothelial cell inflammatory and angiogenic potential.
… in SK activity in human umbilical vein endothelial cells resulted in endothelial activation, as indicated by the heightened expression of adhesion molecules, and further sensitized the cells to subliminal doses of inflammatory cytokines. This corresponded with enhanced neutrophil binding …
-
Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… driven by vascular inflammation that begins with endothelial dysfunction. The endothelium, which lines blood vessels, plays a critical role in regulating vascular tone and immune cell interactions. In response to inflammatory stimuli, such as cytokines, endothelial cells become activated, …
-
Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… the circulation to sites of tissue injury. The endothelial expression of cell adhesion molecules, namely the selectin family, mediates the initial adhesive interactions between leukocytes and the endothelium. Immune cell infiltration is often involved in the initiation and progression of several …
-
The Effects of Macronutrient Composition on Oxidative Stress and Inflammation in Overweight and Obese Humans
… are gaining attention for their contribution to endothelial dysfunction and CVD. We showed that acute meals high in SFA increased a marker of endothelial activation (ICAM-1) which could contribute to the atherogenic associations with SFA. Conversely, including n-3FA in a high fat meal acutely …
-
The role of the HIV-1 Tat protein in acute stroke: more than just a transactivator of transcription?
… HIVinduced chronic inflammation may initiate endothelial dysfunction or accelerate vascular injury from other disease processes. Viral proteins such as the transactivator of transcription (Tat) are emerging role-players in HIV disease pathogenesis and have a putative role in HIV-associated …
-
THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES
… for monocytes; CD206 for macrophages; CD202b for endothelial cells; CD172a for cardiomyocytes; CD66b for neutrophils; CD41a for total platelets). For targeted (Olink) and untargeted (HPLC-MS/MS) proteomic profiling, EVs were further purified by size exclusion chromatography. Selected protein …