Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 855 for “"Endothelial Cells"”.
-
Characterization of endothelial cells of lymphatic vessels
Endothelial cells form the inner lining of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic …
-
The Role of EHD2 in Endothelial Cells
… An increase in long-term migration in endothelial cells was observed and suggested that EHD2 impacts the RhoA pathway instead of the Rac1 pathway. This lead to the hypothesis that EHD2 controls a part of the RhoA pathway. This hypothesis is supported by the loss of filamentous actin and …
-
Lipoprotein receptors in cultured bovine endothelial cells
Endothelial cells take up and degrade both low density lipoproteins and low density lipoproteins which have been modified by acetylation (AcLDL). In this study, receptors that may be involved in the uptake of these lipoproteins were characterized. The cells used were aortic endothelial cells …
-
Regulatory roles of endothelial cells in cancer
… describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine …
-
THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… in vitro and in vivo, vascular smooth muscle cells (VSMCs) actively participate to VC. In contrast to the wide studies on VSMCs, the role of endothelial cells (ECs) has been poorly investigated. It’s known that ECs have a dynamic nature and following particular stimuli they can …
-
The effect of free fatty acids on endothelial cells
… acids (FFA) are alone sufficient to decrease endothelial cells. This hypothesis was tested by incubating porcine aortic endothelial cells (PAECs) with various oxidized PUFAs and saturated FFAs. Twenty hour exposure of PAECs with the oxidized PUFAs (0-100[mu]M) linoleic acid, eicosapentaenoic …
-
Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… Hutchinson Gilford Progeria Syndrome (HGPS) cells and aging cells, implicating dysfunctions of lamin A/C in aging process and atherosclerosis, as HGPS is caused by a mutated form of lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells that …
-
Identifying factors that promote tensional homeostasis in endothelial cells
Various types of mammalian cells have an exceptional ability to adapt to externally applied mechanical stresses and strains. Because of this adaptation, cells can maintain their endogenous cytoskeletal stress at a preferred (homeostatic) state. This homeostasis of mechanical stress in cells, also …
-
Phenotypic and functional analysis of organ specific endothelial cells
… functions. To achieve this transfer, the flowing cells must adhere to the endothelium and migrate through the vessel wall. Though this process follows common stages during recruitment in different organs, there is also specialisation in underlying molecular mechanisms. The main aim was to further …
-
Characterization of the endothelial cells response to trophoblast debris
… the maternal body and exposes various maternal cells to a large amount of fetal/placental material. Preeclampsia, a major complication of pregnancy, is characterized by systemic maternal endothelial cell dysfunction and exaggerated inflammation. It is hypothesized that substances, including …
-
Involvement of endothelial cells and macrophages in mycobacterial infections
… intracellular pathogen targeting host cells, predominantly macrophages, to establish an infection. Endothelial cells form a barrier that has to be crossed by the bacilli in the establishment, and subsequent dissemination of mycobacterial infection. The present study was undertaken to …
-
Modelling the movement of superparamagnetic beads engulfed in endothelial cells
Colonization of porous scaffolds with cells is of increasing importance for various tissue engineering applications. Controlled placement of human umbilical vein endothelial cells (HUVECs) within a micro-porous, poly-caprolactone scaffold is facilitated with superparamagnetic beads introduced to …
-
Force-mediated adhesion strengthening in endothelial cells at adherens junctions
Cells respond to the application of force with a variety of biochemical responses modulating their shape, structure, function, and proliferation. Two force-responsive links between the inside and outside of a cell are integrin proteins, which link a cell to the extracellular matrix (ECM), and …
-
Flow-induced mechanotransduction in cell-cell junctions of endothelial cells
Endothelial cells show an unexpected behavior shortly after the onset of laminar flow: their crawling speed decreases ~40% within the first 30 min, but only in a confluent monolayer of endothelial cells, not in subconfluent cultures, where cell-cell interactions are limited. This led us to study …
Page 1 of 43