Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1562 for “"Endothelial"”.
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Mechanisms of Western-Diet Induced Endothelial Stiffening: Endothelial CD36 and Long-Chain Fatty Acids
… increase in the elastic modulus) of the aortic endothelial layer associates with barrier disruption, and both are mediated by endothelial scavenger lipid receptor CD36. Through the use of an inducible, endothelial-specific CD36 knockdown mouse model, we discovered that loss of endothelial CD36 …
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Modelling the Endothelial Glycocalyx Layer
… for blood flow in microvessels coated with an endothelial glycocalyx layer (EGL). Special attention is focused on the effect of the wall layer on the system as a whole and the interaction between blood, EGL and the wall vessel. Interest in this problem is motivated by its implications for …
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Vascular endothelial cell-surface proteoglycans
… layers of normal ("cobblestone") bovine vascular endothelial cells in culture. Treatment of the parent molecules with dithiothreitol caused their complete cleavage and permitted the subsequent separation of the larger and smaller subunits on Sepharose CL4B columns. Removal of dithiothreitol by …
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Defining the human endothelial transcriptome
… to the study of cultured human umbilical vein endothelial cells (HUVEC), we have found approximately 54% of all genes to be expressed at a detectable level in HUVEC under basal conditions. The set of highest expressed genes is enriched in nucleic acid binding proteins, cytoskeletal proteins and …
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Endothelial progenitor cells, uraemic toxins, and the development of endothelial dysfunction in chronic kidney disease.
… the increased risk, with novel factors causing endothelial dysfunction (ED), leading to arteriosclerosis, congestive heart failure (CHF) and sudden death, key to disease pathogenesis. These novel factors include bone marrow (BM) derived endothelial progenitor cells (EPCs), which have key roles …
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Can exercise mediate similar beneficial effects on endothelial function and endothelial reperfusion injury as ischemic preconditioning?
… exercise is able to provide protection against endothelial ischemia reperfusion (IR)-injury (Seeger et al., 2015). However, more research is warranted to further explore the potential of (single bouts of) exercise as a form of preconditioning and to determine the most effective way to employ it. …
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ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION IN THALASSEMIA
… patients, linking them to cardiovascular risk, endothelial function, and iron/heme parameters. Methods included clinical data, biochemical analysis, T2* MRI for iron overload, and carotid Doppler ultrasounds for plaque detection and intima-media thickness. Inflammatory and endothelial markers …
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p38 MAPK Signalling in Endothelial Apoptosis
Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced …
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Anti-vascular endothelial growth factor in ophthalmology
Vascular endothelial growth factor, secreted by the neurovascular retina, acts as an essential regulator in vasculogenesis, angiogenesis, and increased vascular permeability, which plays a critical role in the pathophysiology of ischemia-related retinal illnesses, inducing aberrant …
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Characterization of endothelial cells of lymphatic vessels
Endothelial cells form the inner lining of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic …
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Role Of Gravin In Endothelial Wound Healing
… vivo but expressed at the periphery of cultured endothelial cell (EC). Although the precise role of gravin in human ECs is not yet known, the cortical distribution of gravin in EC suggests that it may be involved in cAMP regulation by targeting PKA and PDE4 to plasma membrane. Several studies …
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Vascular Endothelial Growth Factor In Cortical Development
… both angiogenesis and neurogenesis is Vascular endothelial growth factor A (Vegf). Vegf is a pleiotrophic factor linked to a broad range of effects in neurovascular systems including proliferation, migration and differentiation. Vegf and its receptors (VegfR1, VegfR2, Nrp1, and Nrp2) are …
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The Role of EHD2 in Endothelial Cells
… An increase in long-term migration in endothelial cells was observed and suggested that EHD2 impacts the RhoA pathway instead of the Rac1 pathway. This lead to the hypothesis that EHD2 controls a part of the RhoA pathway. This hypothesis is supported by the loss of filamentous actin and …
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Lipoprotein receptors in cultured bovine endothelial cells
Endothelial cells take up and degrade both low density lipoproteins and low density lipoproteins which have been modified by acetylation (AcLDL). In this study, receptors that may be involved in the uptake of these lipoproteins were characterized. The cells used were aortic endothelial cells …
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Systems biology of endothelial mechano-activated pathways
Multiple signaling pathways are employed by endothelial cells to differentially respond to distinct hemodynamic environments and acquire functional phenotypes, including regulation of inflammation, angiogenesis, blood coagulation, and the vascular tone. In order to understand how these pathways …
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Regulatory roles of endothelial cells in cancer
… describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine …
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THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… to the wide studies on VSMCs, the role of endothelial cells (ECs) has been poorly investigated. It’s known that ECs have a dynamic nature and following particular stimuli they can trans-differentiate and acquire several different phenotypes through the endothelial-to-mesenchymal transition …
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