Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Endosomal sorting complex required for transport (ESCRT)"”.
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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the expression and functional roles in neurodegenerative diseases
Endosomal Sorting Complex Required for Transport (ESCRT) is responsible for trafficking of misfolded proteins, unwanted organelles and ubiquitinated proteins to be degraded by lysosome. Abnormalities in ESCRT proteins have been linked to various neurodegenerative diseases such as Alzheimer's …
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Regulation of autophagosome formation and maturation by neurodegeneration-associated proteins
… into double-membraned autophagosomes, which form as outgrowths from the Ras-related protein 11A (RAB11A)-positive recycling endosomes. Autophagosomes are closed by the endosomal sorting complex required for transport (ESCRT) complex and then released by dynamin 2 (DNM2) before fusing with …
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Structural and biochemical characterisation of pUL7 and pUL51, conserved tegument proteins required for efficient herpesvirus assembly
… simplex virus (HSV)-1 proteins pUL7 and pUL51 form a complex that is involved in secondary envelopment, although their molecular function is not well understood. Neither pUL7 nor pUL51 share appreciable sequence-level homology with any protein of known function, which has frustrated attempts to …
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Using Chemical Probes to Examine Cellular Activities
<p>Chemical probes are valuable tools for investigating rapid cellular processes, such as anaphase in cell division, by allowing for the modulation of protein activity over the course of minutes. In addition, resistance to chemical probes by mutation can provide insight into inhibitor binding …
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Molecular Mechanisms Regulating Chemokine Receptor CXCR4 Signaling and Trafficking
… <p>CXCR4 signaling is tightly controlled by a complex series of events that rapidly terminates its signaling. Activated CXCR4 is rapidly phosphorylated and ubiquitinated by the E3 ubiquitin ligase AIP4 at the plasma membrane. Ubiquitinated CXCR4 is rapidly internalized onto early endosomes and …