Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Endosomal recycling"”.
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A functional analysis of Rab11a and Rab11b in endosomal recycling
Rab11 GTPases are a family of three monomeric G proteins which are involved in a number of cellular processes including cell division, cell migration and cargo trafficking. Rab11a and Rab11b share over 89% sequence similarity, while Rab25 is approximately 60% similar to Rab11a and Rab11b. Both …
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Inhibition of the endosomal recycling pathway to overcome resistance to cancer therapies
… lab and others have found that inhibition of the endosomal recycling pathway may be a promising strategy to downregulate clinically relevant cell surface proteins and to overcome drug resistance. This thesis focuses on two clinically relevant hormone receptors that are strongly linked to the …
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
… transporters, and the potential repurposing of endosomal recycling inhibitors (ERIs) to target these drug-tolerant cells. Additionally, we examined the effects of ERIs on the total protein and surface levels of immune checkpoint proteins. This was done by targeting the recycling of the …
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Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane system
… that spastin functions to mediate the fission of endosomal recycling tubule and have confirmed spastin’s localisation to ER exit sites, but show using synchronised secretion assays that spastin is dispensable for generalised cargo secretion of at least 2 classes of secretory cargo. Finally, …
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Dynamics of Alpha5 Integrin, Paxillin, and Alpha-Actinin During Formation and Disassembly of Adhesions in Migratory Cells
… These vesicles co-localize with markers for endosomal recycling pathway, including the dye FM 4-64 and transferrin receptor staining. Paxillin organizes into dynamic complexes in areas of membrane activity and paxillin from older complexes dissipates in close temporal coordination with the …
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An Oxanthroquinone Derivative Disrupts Ras Plasma Membrane Localization and Function By Inhibition of Acylpeptide Hydrolase and Perturbation of Sphingomyelin Metabolism
… proteins remaining on the PM. G01 also inhibited recycling of epidermal growth factor receptor and transferrin receptor, but did not impair internalization of cholera toxin, indicating suppression of recycling endosome function. In searching for the mechanism of impaired endosomal recycling we …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… suggest that Liposomal aGalCer requires early endosomal recycling for association with CD1d. In the future, we plan to investigate the visual and kinetic sites of α-GalCer:CD1d loading using confocal microscopy, and impact on immunologic synapse formation.</p>
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… turnover of VISTA on the cell surface due to endosomal recycling, we used Antisense oligonucleotides (ASOs) to knockdown VISTA expression on myeloid cells. ASOs are synthetically generated single stranded oligonucleotides that alter messenger RNA to either diminish, recover, or adapt protein …
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Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… connection between the Golgi apparatus and the endosomal compartment, mediated by two parallel trafficking pathways regulated by the clathrin adaptors AP-1A and AP-3 (Owen et al., 2004). Typical cargo molecules sorted along the AP-1A regulated pathway are mannose 6-phosphate receptors (MPRs) …