Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Endosomal disruption"”.
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Understanding the intracellular signalling pathways activated by lipid nanoparticle delivery of mRNA
… of different LNP components and inhibitors of endosomal progression demonstrated that cytotoxicity is driven by the LNP rather than the mRNA cargo, with a clear correlation between LNP-induced endosomal disruption and cytotoxicity established. Overall, this project provides direction on the …
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Light and nanoparticle-based approaches to the control of ion channels and drug delivery
… a drug delivery method based on light-activated disruption of intracellular vesicles after internalization of bio-functionalized mesoporous silica nanoparticles loaded with cargo. We developed an improved synthesis method to optimize size control of mesoporous silica nanoparticles in the 20-200nm …