Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Endosomal Sorting Complexes Required for Transport"”.
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
… plaques is a hallmark of the most common forms of dementia, including Alzheimer’s disease. The Aβ-containing plaques result from pathogenic cleavage of amyloid precursor protein (APP) by secretases resulting in intracellular production of Aβ peptides that are secreted and accumulate …
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… into internal MVB vesicles designates EGFR for lysosomal proteolysis and extinguishes their signaling activity.</p> <p>Ubiquitination is a post-translational modification that underlies some aspects of membrane protein trafficking. Ubiquitin modification allows EGFR recognition by endosomal …
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Structural and Functional Characterization of the Endosome-associated Deubiquitinating Enzyme AMSH
<p>The endosomal sorting complexes required for transport (ESCRT) machinery is a ubiquitin-dependent molecular mechanism made of up of four individual complexes: ESCRT-0, -I, -II, III, that is necessary for regulating the degradation of cell surface receptors directed towards the lysosome. Not only …
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Quantitative Analysis of Integrin Trafficking and Focal Adhesion Turnover to Study Integration of Early Endocytic Trafficking, Signaling and Migration
Pages 8-153 are misnumbered as pages 9-154.
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Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
… proteins identified in HSV-1 virions. The final formation of mature virus particles requires the membrane wrapping of tegumented capsids in the cytoplasm, a process termed secondary envelopment. This process involves the coordination of numerous viral and cellular proteins and results in …