Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Endoreplication"”.
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Isolation and Characterization of Two siamese Phenotypic Modifiers and Their Role in Endoreplication and Trichome Development
… that ENS1 regulates trichome branching in an endoreplication-independent manner. Mutations in ENS1 also enhance the multicellularity of sim mutant trichomes indicating that ENS1 plays a role in the regulation of the cell cycle during trichome cell differentiation. We have shown that ENS1 is …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
… slight delay of G1/S-phase transition but absent endoreplication in hepatocytes. In contrast, cyclin E2-/- mice showed over-expression of cyclin E1 and prolonged cdk2 kinase activity leading to earlier and sustained DNA synthesis. Higher DNA synthesis in cyclin E2-/- mice did not result in …
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Isolation and characterization of the SIAMESE family: a novel class of cell cycle regulators in plants
… to suppress mitosis as part of the switch to endoreplication in trichomes. We demonstrate that SIM encodes a novel 14kD protein that is part of a small Arabidopsis gene family comprised of four members. Homologs exist in other dicots and in monocots, although no obvious animal homologs have …
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Characterization of the Role of Mcm10 in DNA Replication in Drosophila melanogaster
… the Mcm10 mutant strains showed defects in endoreplication and packaging of DNA within the nuclei of salivary glands. By understanding the various roles of Mcm10 we can help elucidate the biological functions of this well conserved protein as well as provide information on the domains of the …
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The B55α/PP2A Holoenzyme in Cell Cycle Exit, Maturation/Differentiation, and Cancer
… expression of B55α in PC3 cells results in endoreplication. Altogether these suggest that reduced B55α expression in these cells confers a growth advantage in PCa cell lines, which is extinguished when B55α is reintroduced, supporting the notion that hemizygous deletion of PPP2R2A in …