Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Endoplasmic reticulum-associated degradation"”.
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Hrd1 Partners In Endoplasmic Reticulum-Associated Degradation
… misfolded proteins. A main component of PQC is Endoplasmic Reticulum (ER)-Associated Degradation (ERAD), which controls the degradation of proteins synthesized in the ER. Aberrations in ERAD have been linked to malignancies such as sarcomas, breast, and pancreatic carcinomas, as well as …
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Using VHHs to study the function and control of the E2 Ubiquitin-conjugating enzyme UBC6e
Endoplasmic reticulum-associated degradation (ERAD) is essential for protein quality control both during stress and at steady state. We found that an E2 ubiquitin-conjugating enzyme UBC6e contributes to a new layer of homeostatic control, in which ERAD activity itself is regulated …
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Utilizing Drosophila S2 Cells as a Model System to Determine Underlying Mechanisms of ER-associated Degradation
… degraded through a multi-step process known as endoplasmic reticulum-associated degradation (ERAD). Underlying mechanisms for ERAD of membrane proteins, especially those with multiple membrane-spanning segments, are poorly understood. There are currently many unknown aspects of ERAD including …
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Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… and stimulating lipogenesis did not reduce DGAT2 degradation. Monoacylglycerol acyltransferase (MGAT) enzymes, MGAT2 and MGAT3, are closely related to DGA T2 and produce the DGA T2 substrate, diacylglycerol. MGA T2 and MGA T3 interact with DGAT2 and appear to stabilize it. We determined that …
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Differential regulation of the phosphorylated and dephosphorylated forms of the ubiquitin-conjugating enzyme Ubc6e
… and misfolded proteins that accumulate in the endoplasmic reticulum (ER) during energy deprivation, hypoxia, or viral infection. Ubc6e is an ER-localised ubiquitin-conjugating enzyme that plays an important role in the proteasomal degradation of misfolded proteins and can be phosphorylated at …