Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Endoplasmic reticulum(ER) stress"”.
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Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease
… evidence suggests that incretin mimetics exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration. In a recent pilot clinical trial, Liraglutide rescued the decline of the cerebral glucose consumption in Alzheimer’s disease (AD) …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of rapamycin (mTOR), which couples energy and nutrient metabolism to …
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
… represents the fourth most common cause of cancer-associated death in the United States. Little progress has been made in understanding how proteotoxic stress affects rapidly proliferating pancreatic tumor cells. Endoplasmic reticulum (ER) stress occurs when protein homeostasis in the ER lumen …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… and that accumulation of misfolded N-CoR in the ER induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR). Although accumulation of misfolded proteins is known to trigger UPR-induced cytotoxic cell death in several neurodegenerative disorders, APL cells are …
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Role and regulation of mitochondrial permeability transition in cell death
The role of the Mitochondrial Permeability Transition (MPT) in apoptosis and necrosis is controversial. Here we show that the MPT regulates the release of cytochrome c for apoptosis during endoplasmic reticulum (ER) stress by remodeling the cristae junction (CJ). CEM cells were treated with the …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
The project aimed to provide a mechanistic understanding of the effect of endoplasmic reticulum (ER) stress on the differentiation of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. …
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Characterization of The Role of Carma3 In Endoplasmic Reticulum Stress-Induced Nf-Κb Activation
<p>Endoplasmic reticulum (ER) stress-induced inflammation plays an important role in the progression of many diseases, such as type II diabetes, insulin resistance, cancers, and so on. NF-κB is believed to be a central regulator of ER stress-induced inflammation. However, studies on how ER stress …
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Investigating WDR12 as a Therapeutic Target in Breast Cancer
Breast cancer is the most diagnosed and lethal cancer globally in women. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining through genetic screens suggests that the ribosome biogenesis protein WDR12 is essential for breast cancer cell …
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Herp Reduces ER Calcium Content by Proteasomal Degradation of SERCA
Herp, an endoplasmic reticulum (ER) stress inducible protein, reduces ER Ca2+ content in neurons and prevents their apoptosis. An understanding of the mechanism by which Herp decreases ER Ca2+ content requires studies of Herp interacting proteins, which could be SERCA and the proteasome. Herp may …
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Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… a major contributor to the pathogenesis of Escherichia coli 0157:H7. Prior reports suggest that Stx-2 increases necrosis and apoptosis of a variety of host cells including those of endothelial origin as well as immune cells such as neutrophils (156). However, the role Stx-2 plays in delayed …
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Involvement of the Sigma-1 Receptor in Neuronal Cell Death and Alzheimer's Disease
… (Sig-1R) is implicated in many neurodegenerative diseases such as Alzheimer’s Disease (AD). Recently, agonists of the Sig-1R have been found to be neuroprotective in AD and provide significant improvements in symptoms. The hallmarks of AD are aggregation of amyloid-β (Aβ) plaques and …
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Characterization of aortic carboxypeptidase-like protein mutations that cause Ehlers-Danlos syndrome
Ehlers-Danlos Syndrome (EDS) is a hereditary connective tissue disease that can cause a wide range of symptoms throughout the body. There are currently 14 different subtypes of EDS based on the molecular genetics of the disease with many subtypes due to mutations in collagen genes. Classical-like …
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Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is the master regulator of the cellular antioxidant response upon exposure to xenobiotics. In addition, NRF2 induces the expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… currently threatens 3.9 billion people, a number expected to rise to 6.1 billion by 2080, yet no specific antiviral treatments are available despite 80 years of research. Cyclosporine A (CsA), an immunosuppressive drug, has emerged as a potential broad-spectrum antiviral effective against …
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The Role of Sphingosine Kinase 2 in Cell Growth and Apoptosis
… formation of sphingosine-1-phosphate (SIP). Whereas, SphKl stimulates cell growth and survival, it was found that when overexpressed in mouse NIH 3T3 fibroblasts SphK2 enhances caspase-dependent apoptosis in response to serum deprivation, independently of S1P receptors. Sequence analysis …
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
Liver cirrhosis is a leading cause of death worldwide, with the prevalence of cirrhosis on the rise. Cirrhosis is driven by various etiologies, including liver injuries from diabetes, obesity, metabolic disorders, and alcohol use. Central to the progression of chronic liver disease to cirrhosis is …
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Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD
… (NASH) is thought to occur through interacting mechanisms of cellular stress. Lipids accumulate within hepatocytes, making cells more susceptible to insult and less able to respond to challenges, leading to progression from simple steatosis to inflammation. <br/><br/>Endoplasmic …
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The Molecular Mechanisms Underlying the Cancer Killing Effect of Interleukin-24
<p>Interleukin-24 (IL-24) is an immunomodulatory cytokine that also displays specific anti-tumor effects across many cancer cell types. The tumor suppressor activities of IL-24 include inhibition of angiogenesis, metastasis, toxic autophagy, cancer-specific apoptosis, and sensitization to …
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The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation
… connection is crucial for establishing proper neural circuit excitability throughout development stages, and serves an essential role in maintaining excitatory/inhibitory (E/I) balance in the central nervous system. In this thesis, I discovered potential signaling pathways that contribute to …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
The cellular stress response represents an essential mechanism that enables cells to adapt to an array of environmental and physiological conditions. Given the importance of these adaptive responses, it comes as no surprise that dysregulation of the stress response has been strongly implicated in …
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