Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Endophilin"”.
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MOLECULAR MECHANISMS OF THE FORMATION OF ENDOCYTIC PATCHES AND THE INITIATION OF ACTIN POLYMERIZATION IN FAST ENDOPHILIN MEDIATED ENDOCYTOSIS
… macronutrients and transmembrane receptors. Fast endophilin mediated endocytosis (FEME) is a clathrin independent endocytic pathway that is responsible for the uptake of numerous receptors, many of which are major drug targets, including the exclusive uptake of the β1-adrenergic receptor (β1-AR). …
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Understanding Membrane Curvature Sensing
… combined with recognition of specific cargo. Endophilin consists of a curvature-sensitive BAR domain followed by an SH3 (Src-homology 3) domain and has recently been identified in a clathrin-independent endocytosis pathway, FEME (fast endophilin-mediated endocytosis), involved in the uptake of …
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Engineered Cytoskeletal Arrays Reveal Mechanisms Of Membrane Transport And Tubulation
… the microtubule, yet, the BAR domain protein endophilin is necessary for robust tubulation. Alternatively, in the presence of a physiological lipid mixture (LM-GUVs), kinesin-1 can readily tubulate Myo1c-tethered cargo at actin/microtubule intersections, with no significant change upon …
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cpg2 encodes a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
… CPG2 binds to the actin cytoskeleton and to endophilin B2, a member of a family of proteins involved in membrane trafficking. RNAi-mediated knock-down of CPG2 increased the number of postsynaptic clathrin-coated vesicles, some of which trafficked NMDA receptors, and disrupted the …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
… G protein mimetic nanobodies, miniG protein, and endophilin SH3 domains using NMR and biophysical techniques. In Chapter 3, successful cloning, expression in insect cells and purification of β1ARhICL3 chimera in detergent micelles together with expression and purification of intracellular binding …
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Untersuchungen zum Zeitverlauf der Transmitterfreisetzung an einer glutamatergen Synapse
… an Knockout-Tieren des präsynaptischen Proteins Endophilin, die Glutamat nur im sogenannten Kiss-and-run-Modus freisetzen können. Ferner zeigte sich, daß der Zeitverlauf der synaptischen Ströme von den exprimierten Synaptotagmin-Isoformen, von Calcium und von Proteinkinase-C-abhängiger …
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The Regulation of Lipid Metabolism and Mitochondrial Quality Control in Health and Disease
… we found that lipin-1, a PA phosphatase, and endophilin B1 (EndoB1) are critical for DAG accumulation and effective mitochondrial clearance. </p><p>Through this work, we show that two proteins critical in quality control mechanisms also play significant roles in energy homeostasis. We aim to …