Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Endophenotypes"”.
-
Identification of Anxiety Endophenotypes Using Multidimensional Measures of Attention
The relationship between attention bias and anxiety has been robustly supported across paradigms and disorders; however, most published studies have ignored the known multidimensional nature of attention, and instead proceeded in measuring attention bias as a unitary construct, resulting in a lack …
-
Oxytocin and Genetic Links with Eating Behaviours and Relevant Endophenotypes
Oxytocin (OXT) is an ancestral neuropeptide hormone essential in the regulation of human behaviours vital for sustaining life such as food intake and reproduction. Importantly, these behaviours have strong associations with the brains reward circuitry. To date, there has been little OXT-genetic …
-
Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… drug use. Several antecedent behavioural endophenotypes and perturbations in underlying reward-related circuitry have been linked with increased vulnerability of the development of addiction. To what extent these behavioural and neural markers pre-exist or are induced by drug exposure is …
-
An Investigation of Eating Disorder Neurocognitive and Behavioural Endophenotypes in Twins
… relatives suggesting that they may be endophenotypes. Aims: The aim of this study was to examine cognitive styles, emotional processing and behavioural traits in female twins with eating disorders in order to explore their genetic basis. Such investigations will increase our knowledge …
-
Lexical-semantic parameters as robust endophenotypes of abnormal cognitive decline in ageing
The objective of this dissertation was to characterise the relative contribution of genetic influences to individual differences in cross sectional performance and decline of semantic-lexical abilities and to investigate whether these linguistic effects indicating semantic degradation are sensitive …
-
The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
… aspects has been stressed. Furthermore, endophenotypes which link complex traits with their respective biological underpinnings and thus bridge the gap between gene and behaviour have begun to be included in research efforts. In accordance with this approach, this thesis aims to further …
-
The Relationship Between Two Endophenotypes of Psychosis in Volunteers with Schizophrenia and Bipolar Disorder
Background: Deficits in smooth pursuit eye movements are an established endophenotype for schizophrenia (SZ) and are being investigated as a potential biomarker for psychotic bipolar disorder (BDP). While the molecular determinant of the physiological deficit is still unclear, considerable research …
-
The molecular genetics of bipolar affective disorder : South African populations, endophenotypes, and environmental influence
… were therefore used as quantitative markers or endophenotypes of BPD. The quantitative linkage analysis indicated that a variant in the region of 13q32 may influence the development of novelty-seeking-related traits in the largest Afrikaner pedigree, while the personality trait, ""Stability"", …
-
Cognitive task performances as biomarkers & candidate endophenotypes in childhood neurodevelopmental disorders: ADHD & autism
Autism spectrum disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) are both defined on the basis of behavioural impairments and there is no informative biological test available for the diagnosis of the two disorders yet. The current diagnostic criteria adopt hierarchical approach …
-
A multidisciplinary investigation of underlying pathways in ADHD: A study of ADHD genes, endophenotypes and phenotypes
This thesis adopts a multidisciplinary approach, combining cognitive-experimental and physiological data, with quantitative and molecular genetic analyses, to investigate pathways from genes to ADHD behaviours.<br/><br/>In chapter 2 we investigated socio-demographic factors as contributors of …
-
Investigating objective markers of ADHD across development: Micromovements and reaction time variability
… research has demonstrated the importance of endophenotypes, intermediate constructs between genotype and phenotype which index the risk for developing a particular disorder, in better defining developmental pathways to ADHD. This study involved an investigation of two promising candidate ADHD …
-
The serotonin transporter gene (SLC6A4) shows differential regulation between children with ASD and typically developing children in a South African population
… loci associated with ASD or specifically ASD endophenotypes. This may aid in earlier interventions for ASD if molecular biomarkers were identified. The serotonergic system has a longstanding association with ASD, and the differential expression of the serotonin transporter gene (SLC6A4) is …
-
Age and IQ as Potential Moderators in the Relation Among Endopheonotypes and Expressed Behaviors in Children With Autism Spectrum Disorder
<p>The current study examined how certain endophenotypes (i.e., local processing ability, mental flexibility, planning, and disinhibition /inhibition) are related to specific expressed behaviors (i.e., acting out behaviors, social insight deficits, social contact problems, anxious/rigid behaviors, …
-
ASMT gene polymorphisms are associated with Autism Spectrum Disorder (ASD) symptom severity in a South African population
… partitioning of the ASD individuals into ASD endophenotypes, to reduce phenotyping heterogeneity. This study found SNPs previously associated with ASD in the promoter and intronic region. Additionally, this study found novel SNPs, and a SNP in a putative transcription factor binding site not …
-
Lipidomic Dysregulation in Alzheimer's Disease: Relation to Genetics, Neuroimaging and Other Biomarkers
… the hypothesis that TGs would associate with AD endophenotypes, based on their fatty acid composition. Diagnostic groups (cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD) differed on two principal components extracted from 84 serum TG levels. Fish oil-type and olive …
-
The neuropsychological endophenotype of specific language impairments and autism spectrum disorders: Category or continuum?
… spectrum disorders (ASD) neuropsychological endophenotypes and to clarify the nature of overlap between SLI and ASD. Group differences in cognitive functioning, epidemiological factors including proband comorbidity and health problems, and familial data in 39 SLI children and 89 ASD children …
-
The Quantitative Genetics of Neurodevelopment: A Magnetic Resonance Imaging Study of Childhood and Adolescence
… and psychopathology, and also may identify endophenotypes for molecular genetic studies on brain development. We performed a comprehensive statistical genetic study of anatomic neuroimaging data from a large pediatric sample (N=600+) of twins and family members from the Child Psychiatry …
Page 1 of 2