Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"Endophenotype"”.
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Biased information processing as an endophenotype for depression
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An Exploratory Study of Endophenotype Markers for Schizophrenia
… strategy to address this issue is the use of endophenotype markers. The aim of this PhD thesis is to explore the validity of selected candidate endophenotype markers for schizophrenia by establishing the evidence that they may have some or indeed any relationship with the genetic risk for the …
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Inhibition of Gamma Oscillations as a Neurophysiological Endophenotype of Schizophrenia
… to assess frontal inhibition as a potential endophenotype of SCZ. Objectives The first objective was to quantitatively assess transcranial magnetic stimulation (TMS) motor cortex measures of inhibition and excitation in obsessive-compulsive disorder (OCD), major depressive disorder (MDD) and …
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Arbitrary associative memory: a candidate cognitive endophenotype for probable Alzheimer's disease
… for probable AD. The investigation of cognitive endophenotypes for probable AD, or cognitive markers of liability to the condition that are theoretically closer to its genetic mechanisms than its clinical phenotype, might assist in the identification of susceptibility genes for AD. This is …
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The neuropsychological endophenotype of specific language impairments and autism spectrum disorders: Category or continuum?
… spectrum disorders (ASD) neuropsychological endophenotypes and to clarify the nature of overlap between SLI and ASD. Group differences in cognitive functioning, epidemiological factors including proband comorbidity and health problems, and familial data in 39 SLI children and 89 ASD children …
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Suicidal Ideation and Treatment-Resistant Depression: Clinical Endophenotype Characterization and Exploration of Novel Brain Stimulation Interventions
Suicide is a highly stigmatized symptom construct associated with multiple psychiatric conditions. Over 700,000 individuals across the world die by suicide annually. Major depressive disorder (MDD) is the most common co-morbid psychiatric illness in suicide completers. Suicidal ideation (SI) is …
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Cognitive task performances as biomarkers & candidate endophenotypes in childhood neurodevelopmental disorders: ADHD & autism
… whether the biomarkers represent putative<br/>endophenotype.<br/>The findings suggested that even though the core diagnostic criteria of ADHD and ASD are entirely different, they can co-occur possibly due to shared risk. The neuropsychological data revealed that the poor inhibitory control and …
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Investigating objective markers of ADHD across development: Micromovements and reaction time variability
… research has demonstrated the importance of endophenotypes, intermediate constructs between genotype and phenotype which index the risk for developing a particular disorder, in better defining developmental pathways to ADHD. This study involved an investigation of two promising candidate ADHD …
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Biomarker-And Pathway-Informed Polygenic Risk Scores for Alzheimer's Disease and Related Disorders
… heterogeneity, we hypothesized that PRS based on endophenotypes, and pathway-relevant genetic information would be particularly informative. In the first study, data from the NIA Alzheimer’s Disease Neuroimaging Initiative (ADNI) was used to develop endophenotype-based PRS based on amyloid (A), …
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Methods Development in Inflammatory Bowel Disease
… population of IBD patients to date in a dense endophenotype study. Using a stratified analysis to test for endophenotype-independent risk loci yielded five genes of interest. Three of the genes, TNFSF8, HLA-DQB1, and CHRNA4, were shown to increase risk of disease and two of the genes, ADCY7 and …
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Neurocognitive risk and protective factors in addictive disorders
… of protracted use. To address this question, endophenotype research using stimulant-dependent individuals’ biological siblings has been used to investigate traits implicated in the pathology of addiction. Impairments present in both groups suggest an underlying risk-state for dependence, while …
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The serotonin transporter gene (SLC6A4) shows differential regulation between children with ASD and typically developing children in a South African population
… loci associated with ASD or specifically ASD endophenotypes. This may aid in earlier interventions for ASD if molecular biomarkers were identified. The serotonergic system has a longstanding association with ASD, and the differential expression of the serotonin transporter gene (SLC6A4) is …
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Lexical-semantic parameters as robust endophenotypes of abnormal cognitive decline in ageing
… hypothesise that the presence of the “semantic endophenotype” in people carriyng the ApoE vulnerability mutation might be associated with atrophy in areas early affected by neuropathology due to AD and involved in semantic memory retrieval. Using lexical semantic competency in aMCI carriers as …
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Neural Indicator of Altered Mismatch Detection Predicts Atypical Cognitive-Perceptual Experiences in Psychotic Psychopathology
… of mid-latency mismatch detection as a candidate endophenotype and intervention target.
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The Relationship Between Two Endophenotypes of Psychosis in Volunteers with Schizophrenia and Bipolar Disorder
… smooth pursuit eye movements are an established endophenotype for schizophrenia (SZ) and are being investigated as a potential biomarker for psychotic bipolar disorder (BDP). While the molecular determinant of the physiological deficit is still unclear, considerable research has shown deficits in …
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Cerebral hemodynamic response to faces and emotions in infants at high risk for autism
… of neuroimaging markers of a functional endophenotype at six months of age that may be associated with high risk of ASD. These results support a model of altered frontal lobe structure through evidence of altered hemodynamic response and/or functional activity in the high risk infant …
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Functional Interplay Between Neurocognitive Decline and Risk Factors in Older Adults: A Multivariate Latent Growth Curve Model of Risk
… episodic memory’s role as a neurocognitive endophenotype for AD. APOE-e4 also associated with lower estimated intelligence and Depression but not Neurocardiovascular history. In sum, the present study found distinct yet identifiable cognitive profiles of risk for neurocognitive decline. …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… in basal MAGE within the PFC is a molecular endophenotype underlying ethanol behavioral sensitivity. Bioinformatics of basal MAGE across the BXD recombinant inbred panel (n=29), derived from B6 and D2 mice, revealed a densely correlated myelin gene network associated with several ethanol …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… behavior is recognized as a complex, behavioral endophenotype with multiple dimensions extending into motor activity, higher level cognition and executive functioning, reward/reinforcing attributes, and motivation. Motor impulsivity refers to the inability to withhold a response or delay …
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Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… 4, respectively, were not observed in the endophenotype at risk for developing stimulant abuse but were rather a consequence of stimulant abuse. These results further clarify the monoaminergic substrates of behavioural flexibility and specify the neural and computational impairments in …
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