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Showing 1 to 18 of 18 for “"Endoperoxide"”.
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Hydroperoxide stimulation of prostaglandin endoperoxide synthase
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Chemiluminescence From the Thermal Decomposition of 1,4-Diphenyl-1,4-Dioxa-2-Benzopyran-3-One. Direct and Indirect Luminescence Involving an Ortho-Xylylene Peroxide
… (37), an endoperoxide similar in structure to the endoperoxide proposed as an intermediate in the chemiluminescent reaction of luminol, is prepared by the addition of singlet oxygen to 1,4-diphenyl-2-benzopyran-3-one. This endoperoxide yields …
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PHOTOCHEMICAL HYDROXYLATION OF 1-METHYLANTHRAQUINONES: SYNTHESIS OF 9`-HYDROXYALOESAPONARIN II
… was believed to go through formation of an endoperoxide. Photolysis of 1-methyl-9,10-anthraquinones using 419 nm light gave the corresponding suggested endoperoxide cleanly, supporting the hypothesis. Reduction of the endoperoxide resulted in oxidation of the ortho methyl group. The scope of …
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Part One: Photochemistry of Aryl Azides. Chemical Properties of the Transient Intermediates. Part Two: Thermolysis of an Endoperoxide. Generation of an O-Xylylene Peroxide (Nitrene)
One. The photochemistry of phenyl azide, 1-naphthyl azide, 2-naphthyl azide, 1-anthryl azide, 2-anthryl azide, 1-pyrene azide, and 2-pyrene azide was examined by laser flash photolysis inert and reactive solvents. The products of direct photolysis of the aryl azides can depend dramatically on the …
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Lipid Targets of the Antimalarial Trioxanes in <i>Plasmodium falciparum</i>
… sesquiterpene lactone, containing a unique endoperoxide pharmacophore. Despite extensive study, the precise antimalarial mechanism of action of trioxanes remains elusive. Heme iron-mediated cleavage of the endoperoxide within the parasite digestive vacuole is hypothesized to generate …
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Singlet Oxygen Oxidation of Guanine, 9-Methylguanine and Guanine-Cytosine Base Pair: Dynamics and Kinetics Revealed by Parallel Gas- and Solution-Phase Experiments and Computations
… spectrometry was utilized to capture unstable endoperoxides in the collisions of hydrated guanine ions (protonated or deprotonated) with <sup>1</sup>O<sub>2</sub> at ambient temperature. Theoretical calculations have strongly supported an intermediate structure of 5,8-endoperoxide rather than …
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Discovery of Alternative Artemisinin Binding Sites in Plasmodium falciparum ATPase-6
… vivax, and knowlesi species. Artemisinin is an endoperoxide lactone extracted from qinghaosu (Artemisia annua L. or sweet wormwood). It and its derivatives possess uncharacteristically rapid action against Plasmodium falciparum. Artemisinin is unique in its effectiveness in deadly cerebral …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… artemisinin is a sesquiterpene lactone with an endoperoxide bridge isolated from the Chinese annual herb qinghao (Artemisia annua L or sweet wormwood). The relatively stable endoperoxide bridge is essential for their antimalarial activity. The synthesis of …
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The effect of the reducing agent triphenylphosphine on arachidonic acid metabolism by prostaglandin H2 synthase
… conversion of arachidonic acid to prostaglandin endoperoxide (PGH2), which is a precursor to a variety of prostaglandins that function as hormones. Gas chromatography combined with mass spectrometry is employed to look for the novel products produced by reaction of triphenylphosphine with …
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Influence of the reducing agent triphenylphosphine on cyclooxygenase-1 metabolism of arachidonic acid
… acid arachidonic acid (AA) to PGG2, a cyclic endoperoxide that also contains a hydroperoxide, which is subsequently reduced to an alcohol in the enzyme to yield PGH2. Reactions catalyzed by COX-1 are significantly influenced by lipid hydroperoxides. The tyrosyl radical that abstracts the 13 …
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Methyl esterification of fatty acids and eicosanoids with a novel reagent trimethylsilyldiazomethane for analysis by gas chromatography-mass spectrometry
… fatty acids (PUFAs) and are generated from endoperoxide precursors of arachidonic acid and related polyunsaturated fatty acids by the enzyme cyclo-oxygenase (COX). The lipoxygenase (LOX) enzymes convert arachidonic acid into hydroperoxy derivatives of PUFAs termed leukotrienes, which play a …
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Genetic association between schizophrenia and type-2 diabetes
… A2, group IVA (PLA2G4A), prostaglandin-endoperoxide synthase 2 (PTGS2) and v-akt murine thymoma viral oncogene homolog 1 (AKT1). The Haploview™ program was applied to check Mendelian errors, to test Hardy-Weinberg equilibrium (HWE) and to estimate linkage disequilibrium (LD) between …
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Mechanisms of Induction and Maintenance of Constitutive Ptgs2 Expression in Colonic Mesenchymal Stem Cells
… of such gastrointestinal insults, prostaglandin endoperoxide synthetase 2: Ptgs2; cyclooxygenase 2) and its downstream synthetic products, most notably prostaglandin E2, support proliferation and modulate the inflammatory immune response, two functions involved in proper injury response. We …
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Part A: Investigation of a newly identified plant Hernandia didymantha Donn, synthesis of phenethyl cinnamide Part B: Selective removal of ascaridol from the essential oil of Chenopodium ambrosioides var ambrosioides Part C: Synthesis of canophyllol analogues
… of one of the components, the monoterpene endoperoxide ascaridol, compound 26. The selective removal of ascaridol was achieved without affecting the other constituents present in the essential oil using either the reaction with zinc in acetic acid or Lindlar Catalyst poisoned with quinoline …
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Manipulating Embryonic Development and Endometrial Function in Ruminants
… receptor gamma (PPARG) and prostaglandin-endoperoxide synthase 2 (PTGS2) in a sex-specific manner. Collectively these results identify the preimplantation period as a susceptible time to maternal obesity in both conceptus and endometrial tissue. Together, these studies aim to provide a …
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3-Funktionalisierte Tetronsäuren und Synthese von HIV-I-Protease Inhibitoren
… Furandionen ermöglicht. Die Photooxidation zu Endoperoxiden gelingt allerdings nur mit 3-Methylbut-2-yliden-Derivaten, deren 2-Wasserstoff am acidesten ist. Ein weiteres Ziel war die Synthese von Endoperoxiden, die an weitere antiplasmodische Wirkstoffe gebunden werden können. Dazu wird …
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Isolierung und Strukturaufklärung terpenoider Inhaltsstoffe aus Montanoa hibiscifolia und Oyedaea verbesinoides sowie Untersuchungen ihrer biologischen Aktivität
1. Die Asteraceae Montanoa hibiscifolia (Benth.) Sch. Bip. wurde phytochemisch untersucht. Aus den oberirdischen Teilen wurden mittels „bio-guided fractionation“ 15 Sesquiterpenlactone (SLs) isoliert. Als biologische Testsysteme dienten der Agardiffusions-Test und der NF-kB-EMSA. Die Strukturen …
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Dietary intervention with whole flaxseed or vitamin D has beneficial effects on leiomyomas in the oviduct of the laying hen
… growth factor-β3 (TGF-β3), and prostaglandin-endoperoxide synthase 2 (PTGS2). Western blots were carried out to determine changes in protein levels for COX-2. There was a slight decrease in the incidence of leiomyomas in the flaxseed group versus the controls. There was no significant …