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Showing 1 to 14 of 14 for “"Endopeptidases"”.
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… metalloproteinases (MMPs) are zinc-dependent endopeptidases that are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and in other diseases. In this study, we report that …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
… metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matix (ECM) components during normal and pathogenic condition. Documented expression of MMPs contributes to tissue remodeling, atherosclerosis, and inflammatory diseases. MMPs are tight regulated by several …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… within the kidney that include the endopeptidases neprilysin (NEP) and thimet oligopeptidase (TOP) that process Ang I directly to Ang-(1-7).
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Biological studies of GPI-anchoring in Trypanosoma cruzi
… homology to other GPI8s and plant endopeptidases containing conserved Cys\r\nand His residues in their active sites. In T. cruzi expressing TcGPI8 mutant alleles\r\n(C198A or H156A), no alteration in GPI-anchoring efficiency or impairment of in vitro\r\ninfectivity, differentiation …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… (MMPs) represent the most prominent family of endopeptidases that are necessary for normal growth and development but are also involved in the disruption of the blood-brain barrier (BBB), neuronal cell death, neuroinflammation and/or neurodegeneration after TBI. Studies of mouse models from our …
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Factors influencing the responsiveness of human bronchi
… cells. Furthermore, the contribution of neutral endopeptidases,<br/>
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
… metalloproteinases (MMPs) are a family of zinc endopeptidases capable of digesting the extracellular matrix (ECM), which is essential for tissue structure and transmitting messages between cells. MMPs play an important role in cancer, controlling cell migration, proliferation, apoptosis, …
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Studies on the Proteolytic Activation of the Membrane Enzyme, Pyruvate Oxidase
… flavin oxidation-reduction state. Activation by endopeptidases such as chymotrypsin corresponds to a reduction of the subunit molecular weight to 56,000 on sodium dodecyl sulfate polyacrylamide gels. However, sedimentation velocity studies combined with quasi-elastic light scattering results show …
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Biochemical Characterization of the Activity and Specificity of ULP1 Family Members
The reversible posttranslational modification, SUMO, modulates the activity of a diverse set of target proteins. Conjugation machinery charges the processed-SUMO so that it can be linked via an isopeptide bond to a target protein. The removal of SUMO moieties from conjugated proteins by …
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Management of wine aroma using biotechnical tools
… Aspergilopepsins-I supplementation (AP-I), acid endopeptidases industrially employed to achieve protein stability. Along with some amino acids and di/tripeptides increase in treated musts, and despite the positive outcomes in wines of some yeast VOCs, the necessary heat-shock treatment applied …
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Expression and glycosylation of meprin isoforms
… meprin B are disulfide-linked, oligomeric metalloendopeptidases in renal brush border membranes. Meprin A contains 90-kDa subunits (α subunits) and is expressed in random-bred and some inbred strains of mice. Meprin B contains subunits of 110 kDa (β subunits) <i>in situ</i>, and the enzyme from …
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a serine protease that has emerged as a central regulator of plasma low-density lipoprotein cholesterol levels. Here, it is demonstrated that PCSK9 is secreted into the blood and that the secreted PCSK9 binds and degrades LDLRs in liver. To …
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
Pathways underlying metabolic reprogramming in cancer remain incompletely understood. We identified the Transmembrane Serine Protease TMPRSS11B as a novel gene that promotes transformation of immortalized human bronchial epithelial cells. TMPRSS11B is upregulated in human lung squamous cell cancers …
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ApoE Receptors in Alzheimer's and CNS Function
Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder and the most common form of dementia over age 65. The predominant genetic risk factor for AD is the ε4 allele of apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have …