Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Endoglin"”.
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THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS
… Bone Morphogenetic Proteins (BMP) and Endoglin in adult hematopoiesis. Several publications have described the importance of BMP signaling in specification of hematopoietic tissue in developing embryos. In Article I and II, we investigate the full role of BMP signaling in adult mice, …
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N-linked glycosylation at position ASN98 of the ALK1 receptor protein: relevance for ALK1 function and HHT pathogenesis
… growth factor beta (TGFβ) superfamily: endoglin and activin receptor-like kinase 1 (ALK1). These mutations result in development of HHT Type 1 and HHT Type 2, respectively. Patients suffering from HHT experience spontaneous blood vessel growth that can lead to telangiectasia, …
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Análise de Variantes Genéticas no gene da Endoglina em Leucemias Linfoblásticas Agudas de Células B Pediátricas
Introduction: Endoglin (ENG, CD105) is a co-receptor part of the transforming growth factor beta (TGF-β) family, described as a powerful marker of the angiogenesis process. Recently, endoglin (ENG) has been increasingly studied in the context of hematopoietic neoplasms. ENG expression is reported …
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Characterisation of BMP Processing and Signalling in Adipocytes
… and angiogenesis. Interestingly, I found that Endoglin, a known co-receptor for BMP9 and BMP10 in endothelial cells, is also highly expressed in adipocytes. Knocking out Endoglin in mouse primary brown and white preadipocytes reduced BMP9 and BMP4 signalling, uncovering a potential new aspect …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… fms-like tyrosine kinase (sFlt-1) and soluble endoglin (sEng) from placental trophoblasts into the maternal circulation promotes endothelial dysfunction associated with pre-eclampsia. The aim of this thesis was to investigate whether modified lipoproteins and/or elevated glucose have a role in …
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Phenotypic and functional analysis of organ specific endothelial cells
… type in response to pro-inflammatory insult (Endoglin, CD34, CD31). Some artefacts of immortalisation were also apparent (VCAM-1 expression in mUCEC-1 and LYVE-1 in s.END). Functional assays indicated small differences in cell types and further microarray analysis elucidated further …
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The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
… canonical endothelium-restricted co-receptor, endoglin. Moreover, using biophysical and biochemical techniques, we have established that TβRIII forms stable complexes with ALK1. Through genetic knockout approaches using CRISPR, we demonstrate that loss of TβRIII impairs ALK1-induced Smad …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… PAH-associated receptors (BMPR2, ALK1, TGFβR1, Endoglin) was evaluated in lung RNA from PMCA4 wild-type and knockout mice by qPCR, showing no significant differences. In vitro, stimulation of human PAECs and HUVECs with TNF-α and cycloheximide (CHX) significantly reduced PMCA4 mRNA and protein …
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Preeclampsia Link to Gestational Hypoxia
… soluble fms-like tyrosine kinase and soluble endoglin. Upstream adverse consequences on the hypoxic ewe included evidence of an angiogenic imbalance in maternal plasma, increased constrictor reactivity in isolated uterine and femoral arteries, impaired glomerular ultrafiltration, increased …
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The role of mast cells in a mouse model of focal cerebral ischaemia
… in both mouse strains. However, endothelin-1, endoglin and matrixmetaloproteinase-9 were highly expressed in the WT mice, but not in the Kit mice forty five minutes post tMCAo. Further studies are required to elucidate whether the absence of these mediators is responsible for the reduced …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… (HHT) is caused by mutations in ENG, encoding endoglin protein which is a coreceptor for BMP9 and BMP10. Endothelial-specific, homozygous deletion of Eng in adult mice (Eng-iKOe) has been shown to model the HHT phenotype, with the development of arteriovenous malformations (AVMs) in the pubic …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… forms a signalling complex, with ALK1 and endoglin, specific to endothelial cells which maintains vascular quiescence. BMP9 and BMP10 are the high affinity ligands for this signalling complex. Administering exogenous BMP9 has been shown to reverse disease in animal models of PAH, so the …
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Preeclampsia, Autoimmunity and The At1 Receptor
… fms-like tyrosine kinase (sFlt-1) and soluble endoglin (sEng). These experiments were also carried out in non-pregnant animals who did not share the same symptoms. This suggests that pregnancy is a requirement for the full spectrum of preeclamptic features. In addition, the placentas and …
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Clinical utility of 3D power doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies
… Fms-like tyrosine kinase (sFLt-1) and soluble Endoglin (sEng)) measured in the first and second trimesters of pregnancy to predict pre-eclampsia in high-risk women.<br/><br/>To determine the added clinical utility and predictive value of these biophysical and biochemical parameters, a …
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Proteomic analysis of genetically stratified grade-I meningioma
… expression of KLF4K409Q/TRAF7 specific protein Endoglin confirmed via both WB and IHC. NF2-/- mutated meningioma-specific one protein, Annexin-3 showed significant expression compared to other meningioma subtypes and NMT, and knocking down of this protein showed reduced Benmen-1 cell …
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Evaluation of suboptimal health status and prospective levels of oxidative stress biomarkers and angiogenic growth mediators with placental anatomy and pathology in normotensive and preeclamptic births
… endothelial growth factor-A [VEGF-A], soluble endoglin [sEng] and soluble VEGF receptor-1 also known as soluble fms-like tyrosine kinase [sFlt-1]) in addition to OS biomarkers (8-epiprostaglandinF2 alpha [8-epi-PGF2α], 8-hydroxy-2-deoxyguanosine [8-OHdG] and total antioxidant capacity [TAC]) …
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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
… fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng), pathognomonic biomarkers identified in preeclampsia. A randomized controlled trial, Preeclampsia Intervention with Esomeprazole (PIE) trial, was conducted in South African women diagnosed with early-onset preeclampsia to investigate …
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Sledování exprese a koexprese endoglinu a P-selectinu v aortě apoE-deficientních myší
… lkaskchvd Sledovn exprese a koexprese endoglinu a P-selektinu v aortapoE-deficientnch my Diplomovprce MonikaBrlicov Vedoucprce:Mgr.JanaRathousk Clprce: Sledovali jsme expresi a vzjemnou koexpresi endoglinu (receptoru III pro TGF- cytokin) a P-selektinu (adhezn …
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Trophoblast Retrieval And Isolation From The Cervix (tric) For Non-Invasive Prenatal Genetic Diagnosis And Prediction Of Abnormal Pregnancy Outcome
… (PAPPA), placental growth factor (PGF), endoglin (ENG), fms-like tyrosine kinase-1 (FLT1), and alpha-fetoprotein (AFP), proteins known to play a role in EVT function, were evaluated in EVT cells from patients that developed PE, IUGR, or EPL, and compared to pregnancies with uncomplicated …
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Stage-Specific Multiomic Analysis of Human Erythroid Differentiation
… of CD71 (transferrin receptor) and CD105 (endoglin), leading to our hypothesis that Epo-dependence in heterogeneous EE populations can be resolved based on changes in the erythroid markers CD71 and CD105, which are dynamically expressed in BFU-Es and CFU-Es. Methods: To define Epo-dependent …
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