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Showing 1 to 20 of 30 for “"Endogenous Retrovirus"”.

  1. Reconstitution and Characterization of Human Endogenous Retrovirus-K

    Lee, Young Nam

    <p>Retroviruses are a family of clinically significant and scientifically fascinating viruses that infect a wide array of organisms from all vertebrate classes. The two hallmark events in the life cycle of retroviruses are the reverse transcription of the single stranded RNA (ssRNA) genome …

    rockefeller Repository record

  2. Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer

    Plummer, Joshua B2012

    … human cell lines for the presence of human endogenous retrovirus K (HERV-K) Env viral RNA (vRNA), protein, and viral particles. We hypothesize that HERV-K proteins are tumor-associated antigens and as such can be profiled and targeted in patients for diagnostic and therapeutic purposes. To …

    uthsc Repository record

  3. The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis

    Freimanis, Graham L.University of Wolverhampton2008

    Human endogenous retroviruses are the remnants of ancient retroviral infections present within our genome. These molecular fossils show similarities with present day exogenous retroviruses but act as typical Mendelian elements that are passed vertically between generations. Despite being repeatedly …

    wlv Repository record

  4. Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software

    VARGIU, LAURAUniversità degli Studi di Cagliari2014

    Human Endogenous Retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the proviral integrated elements to the descendants. Actually, no replication-competent HERV sequence is recognizable in the human …

    cagliari Repository record

  5. Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission

    Chiu, Elliott S., author, VandeWoude, Sue, advisor, Hoover, Edward A., committee member, Ebel, Gregory D., committee member, Funk, W. Chris, committee memberColorado State University. Libraries2019

    Endogenous retroviruses (ERV) are markers of ancient retroviral infections, though evolutionary forces have limited the capacity for ERV replication and virulence. While they are seldom considered infectious alone, they maintain the ability to interact with their exogenous retroviral (XRV) …

    colostate Repository record

  6. Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine

    rycaj, kiera2012

    <p><strong>HUMAN ENDOGENOUS RETROVIRUS K AS A NOVEL TUMOR-ASSOCIATED ANTIGEN FOR DEVELOPMENT OF AN OVARIAN CANCER VACCINE </strong><em></em></p> <p>Publication No.________<br />Kiera Rycaj, B.S.<br />Supervisory Professor: Feng Wang-Johanning, Ph.D., M.D.</p> <p>Ovarian cancer (OC) is the fourth …

    uthsc Repository record

  7. Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers

    Li, Ming2013

    <p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …

    uthsc Repository record

  8. The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry

    Trela, MalgorzataUniversity of Wolverhampton2019

    … are considered contributory factors. Human endogenous retrovirus K10 (HERV-K10) is one such virus as it retained the capacity to produce viral particles in RA synovium. This study set out to explore how HERV-K10 Gag matrix region could contribute to RA pathogenesis and perpetuation, with …

    wlv Repository record

  9. Characterization of the human endogenous retrovirus HERV-­‐K(HML-­‐6) and HERV-­‐K(HML-­‐10) sequences and analysis of their expression

    CADEDDU, MARTAUniversità degli Studi di Cagliari2016

    … composed of sequences originating from exogenous retroviruses that infected the germ line cells over millions of years and are termed human endogenous retroviruses (HERVs). After germ line infection, the retroviral DNA was integrated into the genome and transmitted through vertical transmission in …

    cagliari Repository record

  10. Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability

    Beyer, Ulrike2012

    … einem LTR (,long terminal repeat') des endogenen Retrovirus ERV9 überein. Die Insertion des ERV9-LTR vor den p63-Locus ist nur in Menschen und Menschenaffen (Hominidae) zu finden. Deshalb nehmen wir an, dass die retrovirale Integration sich sehr spät in der Evolution, vor ungefähr 15 Millionen …

    goettingen Repository record

  11. Generation of Transgenic Mice to Evaluate Promoter Activity and Specificity of Two Human Endogenous Retrovirus Long Terminal Repeats = Untersuchungen zur Promotor-Aktivität und -Spezifität von zwei Long Terminal Repeats humaner endogener Retroviren in transgenen Mäusen

    Schönfeld, Regine MargareteLudwig-Maximilians-Universität

    … Promoter Activity and Specificity of two Human Endogenous Retrovirus Long Terminal Repeats Human Endogenous Retrovirus Long Terminal Repeats (HERV-LTRs) comprise 1.8% of the human genome (52.7 Mb). These sequences contain all the signal structures necessary for the regulation of gene …

    lmu-germany Repository record

  12. Retroviruses in the common brush-tailed possum (Trichosurus vulpecula)

    Baillie, Gregory JohnThe University of Waikato1999

    … details the search for, and characterisation of, retroviruses in a marsupial, the common brush-tailed possum (Trichosurus vulpecula). Initial efforts were directed at detecting exogenous retroviruses in possums, but the majority of the work described in this thesis involved the isolation and …

    waikato-masters Repository record

  13. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

    Zhang, HanghangTemple University. Libraries2017

    … cell differentiation, along with activation of endogenous retrovirus (ERV) genes. CDK9 inhibition results in dephorphorylation of the SWI/SNF protein SMARCA4 and represses HP1α expression, both of which contribute to gene reactivation. Based on gene activation, we developed the highly selective …

    temple Repository record

  14. Analysis of variation in PIWI-interacting RNA (piRNA) expression in testes of different mouse strains

    Sierra Rodríguez, Pío AlbertoUniversitat Oberta de Catalunya (UOC)2021

    … for piRNA evolution and piRNA biogenesis through endogenous retrovirus insertions in genes and piRNA clusters.

    catalunya Repository record

  15. Expression and Immunological Characterization of Herv-K Transmembrane Envelope Protein In Human Breast Cancer

    Yin, Bingnan2012

    <p>The human endogenous retrovirus K (HERV-K) <em>env</em> gene encodes envelope protein comprising surface (SU) and transmembrane (TM) domains. Having shown the exclusive expression of SU in human breast cancer and the stimulation of SU-specific immune responses in patients with breast cancer, our …

    uthsc Repository record

  16. Insertionally polymorphic human endogenous retroviruses and their potential role in cancer

    Izydorczyk, MichalOxford Brookes University2022

    In this study a family of endogenous retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members …

    oxford-brookes Repository record

  17. Characterization of anti-tumor T cell specificities to inform engineering of antigen-targeted immunotherapies

    Grace, Elizabeth E.Massachusetts Institute of Technology2021

    … envelope protein of murine leukemia virus, an endogenous retrovirus. When vaccination against this peptide failed to raise a protective T cell response in vivo, we utilized yeast displayed peptide-MHC libraries to identify mimotopes (peptide mimics) of the p15E antigen. Several mimotopes were …

    mit Repository record

  18. New Targets of p53 Regulation: From Aging to Immune Response

    Leary, Robyn2015

    … and p53 -/- cells. Mmergln-int is a murine endogenous retrovirus that is transcriptionally upregulated in response to cellular stress and regulated by a highly conserved p53 response element in the LTR. When overexpressed, the envelope of Mmergln-int is sufficient to decrease cell viability. …

    umn Repository record

  19. The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus

    Soll, Steven J

    <p>The resurrection of inactive endogenous retroviruses allows us to learn about interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia …

    rockefeller Repository record

  20. Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System

    Papp, Eniko2014

    … Fms-like tyrosine kinase 3 (Flt3) exons with endogenous retrovirus (ERV) transcriptional control elements. ERV-Flt3 fusion genes encoded truncated FLT3 (trFLT3) proteins that induced ligand-independent STAT5 phosphorylation and proliferation of hematopoietic progenitor cells. Furthermore, …

    toronto-retro Repository record

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