Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 375 for “"Endocytosis"”.
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Dissecting Synaptic Vesicle Endocytosis
<p>Synaptic vesicle endocytosis is critical for ensuring rapid local recycling of synaptic vesicles to enable ongoing neuronal activity. We utilized the sensitivity and robustness of the pHluorin assay of synaptic vesicle recycling to probe the control of endocytosis spatially and in response to …
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Genetic Dissection of Synaptic Vesicle Endocytosis
… significance of dynamin in synaptic vesicle endocytosis. Specifically, I assessed dynamin 2 function in synaptic vesicle recycling and neurotransmission and investigated the role of dynamin independent endocytosis at the synapse. My data demonstrates that synaptic transmission after …
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
Endocytosis plays a crucial role in regulating the signalling of the epidermal growth factor receptor (EGFR). The internalization of the EGFR can occur through different mechanisms. Clathrin-mediated endocytosis (CME) operates at all concentrations of EGF and in all cell contexts, directing the …
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Requirement and regulation of actin polymerization during endocytosis
Endocytosis, or cell 'eating,' is a process used by cells for functions such as ingesting foreign particles during an immune response, sensing environmental cues during development and fine-tuning communication between synapses during a neuronal transmission. Endocytosis also allows individual …
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Molecular Determinants of Synaptic Vesicle Exocytosis and Endocytosis Coupling
… exocytosis. The coupling of exocytosis and endocytosis allows for continued rapid synaptic transmission; however, the molecular mechanisms of this process are not well understood. This coupling is assumed to be Ca2+-dependent but the exact role of Ca2+ and its key effectors in the regulation …
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A Role for Dynamin-Dependent Endocytosis During Drosophila Gastrulation
… demonstrates a requirement for Dynamin-dependent endocytosis during these contraction events. Using quantitative analysis, I have identified varied cell behaviors during experiments which knockdown the function of <em>dynamin</em>. In addition, I demonstrate the existence of an antagonistic …
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Investigation of caveolae-mediated endocytosis in response to interferon
… on type I interferon’s (IFN) effects on cellular endocytosis. Endocytosis, a vital process in healthy cells used to internalize material, is a likely IFN target. The anti-tumor nature of IFN may be an unintentional byproduct of its antiviral effects, which are designed to halt pathogenic assault, …
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Regulation of Endocytosis of ROMK Channel by WNK Kinase Family
… WNK1 and WNK4 stimulate the clathrin-mediated endocytosis of ROMK, which contributes to the pathogenesis of hyperkalemia in PHAII patients. Intersectin (ITSN) is a multimodular endocytic scaffold protein. The proline-rich domains of WNK1 and WNK4 bind with the Src-homology domain (SH3) of …
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Regulation of Clathrin Mediated Endocytosis and Its Role in Cancer Progression
… dynamic modulation of cell surface proteins by endocytosis. Given this functional connection, it has been suggested that endocytosis is dysregulated in cancer. To test this, we developed In-Cell ELISA assays to measure three different endocytic pathways: clathrin-mediated endocytosis, …
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Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
… to receptor desensitization and/or induce D1R endocytosis. In addition, the D1R is essential for voluntary movement, cognition and reward processes. As such, the D1R is a validated drug target for a multitude of neurological disorders including Parkinson’s disease and neuropsychiatric …
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Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum
… clathrin mediates one of the major pathways of endocytosis from the extracellular milieu and plasma membrane. Clathrin functions with a network of interacting accessory proteins, one of which is the adaptor complex AP-2, to co-ordinate vesicle formation. Disruption of genes involved in …
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Receptor-mediated endocytosis of low density lipoproteins in aortic endothelial cells
Lipoprotein binding and metabolism in actively-dividing (subconfluent) and quiescent (postconfluent) bovine aortic endothelial cells (ECs) were qualitatively investigated by fluorescence microscopy using dioctadecylindocarbocyanine-labelled lipoproteins and by indirect immunofluorescence …
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EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
… 1 (EHBP1) regulate Delta like ligand 4 (Dll4) endocytosis by tethering its caveolar endocytic pit to the actin cytoskeleton.</p>
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Endocytosis mechanism of poly- and lipoplexes in siRNA delivery in HeLa cells
… that stand on the path of the siRNA delivery is endocytosis. Endocytosis is a process by which nutrients, signals and pathogens enter the cells. This process consists of multiple pathways that lead the objects that were ingested by the cells to different intracellular destinations. The chemical …
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Comparison between endocytosis and intracanalicular sequestration of cell-surface antigens in human platelets
… investigators have speculated on the role of endocytosis in platelets to account for the presence of plasma proteins such as fibrinogen and immunoglobulin within platelet organelles. Antibodies binding to cell-surface antigens on platelets can lead to a redistribution of these antigens. When …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… expression interferes with NMDAR-dependent AMPAR endocytosis and LTD, without affecting baseline synaptic transmission. When expressed in vivo, G2CT completely blocks the MD-induced depression of deprived-eye responses after MD without affecting baseline visual responsiveness or …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… activation is linked to cancer progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin endocytosis (NCE), which is activated only after stimulation with high doses of the ligand epidermal growth factor …
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… via cell adhesion molecule (CAM)-mediated endocytosis, a clathrin-/caveolae-independent pathway involving Na+/H+ exchanger 1 (NHE1). ICAM-1 itself plays a key role in transendothelial migration (TEM) of leukocytes, particularly via the transcellular route. This involves endothelial …
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