Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Endocytosi"”.
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
Endocytosis plays a crucial role in regulating the signalling of the epidermal growth factor receptor (EGFR). The internalization of the EGFR can occur through different mechanisms. Clathrin-mediated endocytosis (CME) operates at all concentrations of EGF and in all cell contexts, directing the …
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ENDOCYTIC CONTROL OF CELL-AUTONOMOUS AND NON-CELL-AUTONOMOUS FUNCTIONS OF P53
NUMB is a multifunctional adaptor protein historically recognized for its role in determining cell fate decisions through inhibition of NOTCH signaling, a process achieved via endocytic trafficking. Subsequently, NUMB has emerged as a significant tumor suppressor, particularly in the context of …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… activation is linked to cancer progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin endocytosis (NCE), which is activated only after stimulation with high doses of the ligand epidermal growth factor …
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ROLE OF THE ENDOCYTIC PROTEIN EPSIN 3 IN MAMMARY GLAND TRANSFORMATION
Background: Endocytosis is a crucial mechanism regulating cellular signaling and its dysregulation is linked to cancer. We previously showed that the endocytic protein Epsin 3 (EPN3) is overexpressed in 50% of breast cancers (BC) and amplified in approximately 10% of cases. EPN3 overexpression …