Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Endocytic escape"”.
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Characterization of endocytic escape pathway and its role in adaptive immunity
In dendritic cells, endocytic escape appears critical for the induction of cytotoxic T-cell responses against viruses and tumors, in a process termed cross-presentation. During cross-presentation, dendritic cells present exogenous antigens on MHC class I, and the predominant molecular model for it …
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Deciphering the regulation of perforin-2-mediated endocytic escape in dendritic cells
… most cell types, cross-presenting DCs have leaky endocytic compartments from where internalised proteins can escape into the cytosol for proteasome-mediated generation of MHC-I-binding peptides. Prior to my project, the Kozik lab had identified the pore-forming protein perforin-2 as a dedicated …