Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"Endocrine disruption."”.
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… of chemicals, which are classified as estrogenic endocrine disruptors (EEDs), can bind to ERs or GPERs, thereby interfering with estrogen signaling and causing adverse effects. Zebrafish embryos/larvae are an emerging model used in xenoestrogen studies. However, endogenous estrogen signaling in …
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Intersexuality and Endocrine Disruption in the Amphipod Echinogammarus marinus – From Genes to Physiology
… considered an ideal model to study reproductive endocrine disruption in Crustacea. This study aimed to investigate both the physiology and gene expression in intersex E. marinus with the objective of better understanding their reproductive biology and aid the development of biomarkers of …
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Thyroid hormones and their receptor gene expression as biomarkers of endocrine disruption in harbour seals (Phoca vitulina)
… of certain POPs have been implicated in the disruption of the endocrine system in marine mammals. The main purpose of this study was to assess whether current levels of POP are affecting thyroid hormone physiology of free-ranging harbour seals (Phoca vitulina) in British Columbia (BC), Canada …
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THE INTERPLAY BETWEEN ENDOCRINE DISRUPTION AND GENETICS IN THE PHYSIOPATHOLOGY OF HUMAN NEURODEVELOPMENT: BRIDGING EPIDEMIOLOGY TO MOLECULAR INSIGHTS THROUGH BRAIN ORGANOIDS AND HIGH RESOLUTION OMIC MODELLING
Several epidemiological studies uncovered a strong link between pre- and postnatal exposure to EDCs and impaired development of cognitive functions, attention and social behaviors in children. Nonetheless, the molecular mechanisms underlying such outcomes are yet to be detailed and EDC-induced DNT …
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Hormone analyses of Black-Footed Albatross (Phoebastria Nigripes) at Midway Atoll NWR and Tern Island, Hawaiian Islands NWR
… 1996; Finkelstein et aI., 2003). Studies on endocrine disruption and effects of PCB contamination in wildlife have shown that estradiol and testosterone levels may be ahered and skewed as a result of anthropogenic sources (Fry and Toone, 1981; Grasman et aI., 1996; Auman et aI., 1997). Thus, …
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The potential treatments of osteoporosis and hormone dysregulation caused by female athlete triad syndrome
… female athletes. The triad of physiological and endocrine disruption can develop into conditions of low energy availability, functional hypothalamic amenorrhea, and osteoporosis. This state of interwoven dysfunction occurs in females who participate in endurance sports, excessive exercise, …
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Ecotoxicological assessment of galaxolide and tonalide as contaminants of emerging concern in marine ecosystems
… was also observed that both compounds modulated endocrine disruption biomarkers in small fish. Despite the significant alterations in endocrine disruption biomarkers induced by both compounds, AHTN appeared to be a more potent inhibitor of endocrine activity in the marine environments. This PhD …
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Patterns of intersex prevalence, vitellogenin, and reproductive condition in two commercially harvested fish along a pollution gradient in the Illinois River complex
… upstream sources that contain elevated levels of endocrine-disrupting chemicals (EDCs). Controlled exposures of fish to EDCs in laboratory have produced increased feminization of male gonadal tissue in fish (i.e. intersex condition), elevated levels of the blood lipoprotein vitellogenin (VTG), and …
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Health Starts in the Home: An Assessment of Efforts to Improve Occupant Health through Healthy Building Materials in San Francisco’s Affordable Housing
… to adverse health outcomes such as asthma, endocrine disruption, cancer, neurodevelopmental issues, and reproductive problems (Bayer et al., n.d.; Green Science Policy Institute). Furthermore, these chronic health conditions disproportionately affect low-income populations. Fortunately, …
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Impact of Indirect Potable Reuse on Endocrine Disrupting Compounds in the Potomac River Basin
… to determine the sources and magnitude of endocrine disruption. Endocrine disrupting compounds (EDCs) are exogenous chemicals that interfere with the endocrine system and can cause detrimental health effects at low concentrations. This study aims to understand a best management practice …
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How does a butterfly embryo cope with environmental stress?
… hormone and 20E) to study their effect on endocrine disruption during embryogenesis; both a maternal effect and through direct exposure. Eggs displayed increased sensitivity early in development before serosa formation and were in general more significantly affected as a result of a …
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Metabolism and mechanistic toxicity of environmental pollutants in fish models : integrating in vitro and in vivo systems for ecotoxicological studies.
… populations with different exposure history, the endocrine disruption potential of wastewater effluents, and the description of mechanistic toxicity of natural and anthropogenic pollutants, while considering the influence of different environmental stressors. This work demonstrated that …
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Occurrence, Fate and Transport of the Primary Metabolites of Trenbolone Acetate in CAFO Soils and Surface Water Runoff
Metabolites of synthetic growth promoters used in industrial cattle production pose a demonstrated ecological risk to waterways adjacent to beef feedlot operations. For example, numerous studies have linked reproductive abnormalities in fish species to the presence of 17-α trenbolone and 17-β …
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Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
… histology, demonstrated no evidence of endocrine disruption. Incorporating both sexes did not introduce confounding variability; rather, it strengthened the robustness and interpretability of the dataset, supporting SABV as a critical component of preclinical safety evaluation. To extend …
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Inter-Method Comparison of US EPA Analytical Methods 507 and 508.1 to Test for Atrazine in Kentucky Drinking Water
… to myriad negative health endpoints ranging from endocrine disruption to various forms of cancer, including stomach and ovarian cancer. To date, there is little research examining the current methods used to test for Atrazine and its seasonal variation in drinking water. Drinking water samples …
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Integrated strategies for investigating endocrine mechanisms in Biomphalaria Glabrata as a test organism for androgenic chemical testing
Endocrine and metabolic disease or dysfunctions are of growing concern in modern societies across the globe, underlining the need for continued focus on the development of pharmaceuticals. Subsequent scientific research has revealed a trend in the increase of such abnormalities and expansion of …
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UNDERSTANDING CONDITIONAL MODES OF ACTIONS IN CHEMICAL-INDUCED TOXICITY USING RULE MODELS
… in commercial setups. I also demonstrate that endocrine disruption endpoints extrapolate better into in vivo toxicity when a set of specific conditions are met, such as physicochemical properties associated with good bioavailability. Next, I examined synergistic interactions between conditions …
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Effects of methoxychlor and its metabolites on mouse antral follicles
… my doctoral dissertation is to determine whether endocrine disruption in the normal estrogenic pathway leads to altered sensitivity of the ovaries to environmental chemicals. Specifically, I have used a transgenic mouse model in which estrogen receptor alpha (ESR1) is overexpressed (OE) in several …
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