Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Endocrine Pancreas"”.
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The Development of a Vascularly Implanted Prosthetic Endocrine Pancreas
3cm and 1.5 cm implantable prosthetic units were constructed from biocompatible fabrication materials and consisted of a polyethylene shell containing a centrally positioned acrylic copolymer hollow fibre (M.W. cut-off 100K Daltons), with a 10 cm polyethylene cannula attached at either end. Hollow …
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TMEM27: A Cleaved and Shed Plasma Membrane Protein That Stimulates Pancreatic Beta Cell Proliferation
… transgenic mice with marked hypertrophy of the endocrine pancreas. Tmem27 is expressed in hormone positive cells at early stages of pancreas development and becomes restricted to pancreatic β cells in the mature pancreas. Biochemical characterization revealed that the Tmem27 exists as a dimer …
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Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
<p>Human pancreatic neuroendocrine tumors are rare tumors that form in the endocrine pancreas. Patients with these tumors have limited therapeutic options, and curative intervention is limited to surgical resection. These tumors do, however, consistently express somatostatin receptor type 2 (SSTR2) …
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Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
Traditionally, the exocrine and endocrine cellular compartments of the pancreas have been considered distinct functional systems. However, recent studies suggest a more intricate relationship between the exocrine and endocrine, which may impact pancreatic growth and health. Additionally, …
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Functional Analysis of Daxx In Tumorigenesis of Pancreatic Neuroendocrine Tumors and Embryonic Development
… and ATRX occur in about 30% of pancreatic neuroendocrine tumors (PanNETs). Although lots of progress has been made in studying functions of DAXX, we still do not fully understand how DAXX functions as tumor suppressor in PanNETS and what functions of Daxx are essential for early embryonic …
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Chickens from lines artificially selected for juvenile low and high body weight differ in glucose homeostasis and pancreas physiology
… model for investigating glucose regulation and pancreas physiology. Oral glucose tolerance and insulin sensitivity tests revealed differences in threshold sensitivity to insulin and glucose clearance rate between the lines. Results from real-time PCR showed greater pancreatic mRNA expression of …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… precursor cells to differentiate into acinar or endocrine cells is regulated by a complex network of signaling and transcription factor pathways. P48 is a tissue-specific basic-helix-loop-helix (bHLH) transcription factor, which is essential for pancreas development and function. Mice lacking …
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Effects of hypothyroidism on pancreatic islet development and tissue insulin signalling pathways in the ovine fetus
… late gestation for the normal development of the endocrine pancreas, adipose tissue and kidney. Alterations in organ development in response to hypothyroidism may have short and long term consequences for carbohydrate metabolism, obesity and renal function.
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Early liver formation in zebrafish: a molecular and morphological approach
… tract and its accessory organs - liver, pancreas, and the inner lining of the swim bladder - are derived from the endodermal germ layer. In zebrafish the digestive system starts out as a rod at the embryonic midline, which subsequently becomes patterned and outgrowth of its associated …
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Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)
… and quantitative morphological changes of the pancreas and the kidneys were investigated in several age groups. Some of the parameters were studied in different diet groups, one of them received standard rodent chow, and the other received a carbohydrate-restricted diet until four months of …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… homeostasis. LRRK2 is also expressed in the endocrine pancreas but here its role is completely unknown. Using molecular and pharmacological approaches, the overall aim of this project was to characterize LRRK2 activity in cells involved in glucose homeostasis with a focus on pancreatic …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… insulin secretion by beta cells of the endocrine pancreas. A second VDR target gene we identified in the islet is klotho, a key regulator of phosphate homeostasis. We clearly establish that klotho mRNA and protein are detected in beta cells of mouse islets, at levels sufficient to …
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The equine metabolic syndrome: studies on the pathophysiology of obesity, insulin resistance, and laminitis in equids
… was to characterize the morphology of the equine endocrine pancreas in response to dietary carbohydrate challenge. No effect of dietary carbohydrate was noted on ß-cell surface area (p = 0.12). The change in serum insulin concentration was significantly greater in the high carbohydrate-fed ponies …