Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Endochondral ossification"”.
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Bone growth following demineralized bone matrix implantation requires angiogenesis
Angiogenesis is required for endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear. In this study, we utilize an in vivo model of endochondral ossification in mice by implanting …
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Characterization of a Novel Nuclear Variant of Bmp2 and Coordinate Regulation of Col11a2 and Col27a1 by the Transcription Factor Lc-Maf
… progressively replaced by bone. This process of endochondral ossification requires precisely coordinated expression of extracellular matrix proteins such as the cartilage-specific collagens. In this study, enhancer/reporter assays demonstrated that the transcription factor Lc-Maf inhibits the …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… exposure inhibited chondrocyte hypertrophy and endochondral ossification. Western blot demonstrated that the temporal expression of stabilized beta-catenin in callus tissue was significantly disrupted by alcohol at days 1, 3, 6, 9, and 14 post fracture compared to controls. The disruption in …
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Metal-doped silicate microparticles for collagen scaffold-guided endochondral bone regeneration
Endochondral ossification (EO) describes a process in which bone tissue builds up via a cartilaginous phase. In contrast to classical biomaterial approaches, which address bone regeneration via direct, intramembranous ossification (IO), a collagen scaffold was shown to stimulate endochondral …
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Effects of temperature and density on the facial malformation of hatchery-reared cisco, Coregonus artedi
… during early ontogeny and the beginning of endochondral ossification. The malformation is characterized by an improperly formed vomer and ethmoid bone. Early onset of the malformation suggests physical trauma is not the sole causative factor, and supports diet and/or environment as triggers …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
… are known to play key roles in the regulation of endochondral ossification. However, the issue of whether these two hormones interact with each other to regulate bone functions remains to be established. We investigated how thyroid hormone and retinoic acid interact to regulate cells involved in …
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MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… (PC) molecules in extracellular matrix during endochondral ossification. They reside in a poorly vascularized tissue, as the growth plate, with scarcity of nutrients, representing a good cellular model to study ER-phagy. We found that the nutrient responsive transcription factors TFEB and …
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… induced in some frogs to study the mechanisms of endochondral ossification. The limbs were harvested at a series of early time points ranging from 3 days to 6 weeks after implantation. Standard histology was used to evaluate tissue types and the anatomical relationships. In frogs treated with …
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Developmental Differences and Altered Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
… for its role in cartilage condensation and endochondral ossification. It was hypothesized that the overexpression of Sox9 in the developing mandible would be localized to Meckel’s and hyoid cartilages. Immunohistochemistry performed on the mandibular precursor confirmed an overexpression of …
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The influence of osteochondrosis (OC), in yearling Standardbred horses on subsequent two and three-year old racing performance and the influence of sire on rates of OC in Illinois Standardbred horses
… orthopedic disease that involves the failure of endochondral ossification affecting the articular cartilage. This generally occurs in the early orthopedic development in juvenile horses. Due to this, owners and trainers take great interest in early orthopedic developmental abnormalities as a …
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Ihh Signaling and Muscle Forces are Required for Enthesis Development
… of this tissue occured postnatally via endochondral ossification. We observed a constant and approximately linear increase in the mineral-to-collagen ratio at the mineralizing front within the enthesis at all developmental stages. Using a multi-scale linear elastic model of the tendon …