Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Endocannabinoids"”.
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
… mediated oxygenation of omega-6 derived endocannabinoids, thereby revealing a previously unknown metabolic pathway. The endocannabinoids, anandamide (AEA) and 2-arachidonylglycerol (2-AG), are endogenous lipid mediators that are agonists of cannabinoid receptor-1 (CB1) and cannabinoid …
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Nutritional factors influencing tissue omega-3 metabolism and endocannabinoids levels in experimental models and humans
The nutritional role of dietary fatty acids is quite controversial and often the object of mediatic campaigns either as panacea against all diseases or detrimental for human health. The most recent data are instead showing that it should be considered, in an optimal dietary regimen, the balance …
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CENTRAL NERVOUS SYSTEM CONTROL OF MICTURITION IN RODENTS THROUGH NEUROPROTECTION AND ENDOCANNABINOIDS - DOPAMINERGIC AND CANNABINOID CONTRIBUTION
Micturition consists of reflexes involving the central and peripheral nervous system controlling the bladder and urethra. A better understanding of the underlying contribution of the dopaminergic and cannabinoid systems to the control of micturition could help direct therapeutic modalities for …
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Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… intake of ω-3 PUFAs alters the concentration of endocannabinoids (ECs) in central and peripheral tissues and, since synthetic cannabinoid agonists have been shown to exert anti-atherosclerotic effects, this thesis explored whether a link exists between the endocannabinoid system and the …
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Metabolism of omega-3 endocannabinoids by cytochrome P450s and the role of their metabolites in neurodegenerative diseases
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Modulation of Fatty Acid-Induced Skeletal Muscle Inflammation by the Peripheral Endocannabinoid System.
… system of the central nervous system, in which endocannabinoids act as retrograde neurotransmitters that inhibit synaptic activity. However, recent evidence has indicated that the ECS may also play a key role in the control of fuel and energy metabolism through its ability to modulate signalling …
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Enzymology of lipid metabolism by CYP2J2 as controlled by multiple-ligand binding events
… can be further transformed in the body into endocannabinoids, typically by conjugating the carboxylate headgroups with a variety of biological amines. These endocannabinoids modulate many of the functions associated with cannabinoids derived from marijuana (phytocannabinoids), including …
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Functional Characterization of CRIP1a Knockout Mice
… nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits CB1 receptor activity without affecting CB1 expression. This thesis …
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Central cannabinoid regulation of food intake in chickens
… central nervous system and peripheral tissues. Endocannabinoids differ from other "classical" neurotransmitters because they do not appear to be stored in synaptic vesicles, and they act as retrograde messengers within the brain. The endogenous cannabinoid signaling system includes cannabinoid …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… results in impairments of skilled behaviour. Endocannabinoids have been shown to affect spinal locomotion and stress has been shown to affect spontaneous locomotion therefore, the effect of cannabinoid signaling and stress on motor map expression and behaviour was examined. The first study …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… and was partially due to GABA inhibition via endocannabinoids.
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Ghrelin, Cannabinoids, and Motivation: Increased Food Motivation on Progressive Ratio Paradigm Through MAGL/FAAH Inhibition in a Rat Model
… this system by stimulating the release of endocannabinoids from dopamine cells through its receptor, via increased synthesis and accumulation of membrane bound cannabinoid enzymes. First, we used a progressive ratio paradigm to examine the behavioural effects of blocking cannabinoid …
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Design, synthesis and SAR of small molecules acting on pain pathways
… enzyme involved on the metabolization of endocannabinoids. The aim was to cause an increase of the endocannabinoids concentration which leads to analgesic effect by the potentiation of the endocannabinoid tone. Some of the studied compounds showed inhibitory activity against FAAH at …
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
… fatty acid ethanolamides (FA-EA) and endocannabinoids (EC). These lipid mediators and oxysterols elicit potent bioactive functions in many physiological and pathological processes of the brain and neuronal tissues. They have been investigated for biomarker discovery of ageing, …
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The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
Eicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (PUFA) with neuroprotective and cardioprotective properties. It is thought that some of the actions of EPA may be attributed to its elongated metabolite, the PUFA docosapentaenoic acid (DPA). Docosahexaenoic acid (DHA) and arachidonic acid …
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EFFECTS OF ENHANCING ANANDAMIDE LEVELS ON HIPPOCAMPAL NEUROPHYSIOLOGY AND SHORT-TERM MEMORY PROCESSING IN RATS
The endocannabinoids affect spatial-working memory by altering neuronal activity of pyramidal neurons present in the hippocampus. In this study extracellular action potentials were recorded using multi-neuron electrodes implanted in the CA1 and CA3 subfields of the hippocampus. The acute effects of …
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Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
… of these receptors also increases release of endocannabinoids which act at CB<sub>1</sub> receptors to reduce excitatory transmission. Using submaximal doses of pilocarpine, we found that pilocarpine-induced seizures were more severe in CB<sub>1</sub> KO mice compared to WT mice. Similarly, …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
<p>The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol …
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Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… drive the formation of a neointima. Cannabinoids/endocannabinoids have been shown to elicit antiproliferative, anti-migratory and anti-inflammatory effects, highlighting modulation of the endocannabinoid system as possible therapeutic strategy. The aims of this study were to; (i) develop an organ …
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