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Characterising the roles of mammalian atlastins in the endoplasmic reticulum and beyond

Zlamalova, EliskaUniversity of Cambridge2023

… motor neuron diseases. This project focuses on endoplasmic reticulum (ER) proteins atlastins (ATLs), particularly ATL1, as *ATL1* gene mutations cause the most frequent childhood-onset form of HSP. Using CRISPRi, I engineered ATL1 knock-down (KD) into the i³ human induced pluripotent …

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