Global ETD Search
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Showing 1 to 1 of 1 for “"Endo-lysosomal degradation"”.
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… are inactivated by ubiquitin-proteasome-mediated degradation of their a subunit, which is dependent on prolyl hydroxylation by 2-oxoglutarate (2-OG) and Fe(II)-dependent prolyl hydroxylases (PHDs). In hypoxia, HIF-$\alpha$ is no longer hydroxylated and is therefore stabilised, activating a global …