Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"EndMT"”.
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Coordinated regulation of the snail family of transcription factors by the notch and tgf-0 pathways during heart development
… endothelial-to-mesenchymal transition (EndMT) during cardiac morphogenesis. EndMT is the process by which endocardial cells of the atrioventricular canal and the outflow tract repress endothelial cell phenotype and upregulate mesenchymal cell phenotype. EndMT is initiated by inductive …
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Evaluation of Human Umbilical Vein Endothelial Cells in Blood Vessel Mimics Through Changes in Gene Expression and Caspase Activity
… regarding endothelial-to-mesenchymal transition (EndMT). A trend of decreased endothelial marker gene expression and increased mesenchymal marker gene expression would indicate EndMT. qPCR analysis revealed that increased cell culture duration did not result in EndMT, and in fact increased …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… endothelial-to-mesenchymal transition (EndMT), a phenotype that recapitulates most of the previously observed functional changes that are responsible for dysplasia and fragility of CCM lesions. Ccm1 deletion leads to activation of the MEKK3-MEK5-ERK5-MEF2 signaling cascade resulting in a …
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THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… the endothelial-to-mesenchymal transition (EndMT). Methods. Human aortic ECs (HAECs) were challenged, in an in vitro calcification model, with 2, 2.5, 3, 3.5 mM Pi for up to 7 days. Early morphological changes, gene expression and cell migration were evaluated. Afterwards calcium deposition, …
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Elucidating the underlying mechanisms of diabetic endotheliopathy using patient specific induced pluripotent stem cells
… differences in the transcriptome of DiPS-ECs. EndMT related gene ontology was enriched in DiPS-ECs. Endothelial specific Roundabout protein 4 (ROBO4) is highly involved in pathways related to angiogenesis, barrier stability and endothelial health. Expression of ROBO4 was found to be impaired in …
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UNRAVELLING SEX-DEPENDENT MECHANISMS IN CALCIFIC AORTIC VALVE STENOSIS
… endothelial to mesenchymal transition (EndMT), begin to express mesenchymal adhesion molecules and facilitate monocytes infiltration and local inflammation. These environmental changes induce VIC trans-differentiation into myofibroblast- and osteoblast-like cells. Activated VICs carry …
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… endothelial-to-mesenchymal transition (EndMT) were less sensitised than in homeostatic conditions.<br/><br/>Conclusions: Gli1+ cells are expressed throughout the eye, most notably within the uveal tract and retinal microvasculature. In the context of injury, Gli1+ cells are closely …