Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Encephalomyocarditis virus"”.
-
Sensing of Picornavirus Infections
… of interferons (IFNs) and cytokines. For RNA viruses, which replicate in the cytoplasm, the cytoplasmic RIG-I like receptors are responsible for this sensing. The contributions of these receptors to sensing viruses of the Picornaviridae family were investigated. Using bone marrow derived …
-
Role of Hypoxia-inducible Factor in Kidney Cancer
… ccRCC cells. We also demonstrate that the picornavirus EMCV (Encephalomyocarditis virus) efficiently destroys ccRCC tumour cells in an NF-kappaB- and HIFalpha-dependent manner both in vitro and in a mouse xenograft model. This work provides pre-clinical evidence for the potential use of EMCV in an …
-
The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… response. During the course of infection, many viruses produce dsRNA that can be recognized by two major arms of the innate immune system: the toll-like receptors: TLR) and the Rig-I-like receptors: RLR). Among the TLRs, TLR3 binds dsRNA within the endosomal compartment and initiates signaling …
-
Biochemische Charakterisierung und physiologische Bedeutung eines neuen durch Typ I Interferon induzierten Gens
… die zytopathischen Effekte einer Infektion mit Encephalomyocarditis-Virus (EMCV) und Vesicular-Stomatitis-Virus (VSV) hinauszögert. Dieser Nachweis konnte an zwei verschiedenen Zelllinien erbracht werden, womit sichergestellt ist, dass die antivirale Aktivität kein Positionseffekt der …
-
On the function of the interferon-inducible p53 target gene TRIM22
… IFNs, and many are involved in defence towards viruses, including TRIM22. TRIM22 has been shown to restrict HIV-1, hepatitis B and encephalomyocarditis virus. p53 is probably one of the most important tumour suppressor genes, and is positioned in the centre of signalling pathways that prevent …
-
Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
… in murine cells. Depletion of SRMS impaired virus- or dsRNA-induced expression of type I and III IFNs and ISGs in mouse embryonic fibroblasts (MEFs), mouse hepatoma hepa1-6 cells, and primary mouse lung fibroblasts. Mechanistically, SRMS acted downstream of the RLRs and their adaptor MAVS. …
-
Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
… proinflammatory cytokines, which serve to keep virus infections under control. RIG-I and MDA5 contain N-terminal tandem CARD domains. CARD domains in other proteins are known to mediate protein-protein interactions. MAVS also contain one CARD domain. It has been proposed that the activation of …
-
Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection
Encephalomyocarditis virus (EMCV) is capable of infecting a wide range of mammalian hosts, causing encephalitis, diabetes, myocarditis in mice and primates as well as reproductive disorders in pigs. The severe pathogenicity is considered to be a result of the rapid cell lysis caused by EMCV. This …
-
The interaction of hepatitis C virus and intracellular lipid metabolism
Chronic hepatitis C virus (HCV) infection causes inflammation of the liver, which can lead to fibrosis and cirrhosis over time. Whether liver damage is a consequence of viral infection or is due to an immune mediated response is not clear. Steatosis is a histopathological feature often found in HCV …