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Showing 1 to 20 of 140 for “"Enantiomers"”.
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Differential pharmacology of amphetamine enantiomers
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Separation of enantiomers of Baclofen
… only partial separation of its (+) and (-) enantiomers. X-ray crystallographic, thermal, and polarimetric analyses were perfom1ed on the ( + )- and (-)-salts of the latter co-crystals. The solubilities of these salts in methanol were found to differ by a factor of 4. A solubility diagram was …
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Synthesis and evaluation of β-fluoro-γ-aminobutyric acid enantiomers
… the enantioselective synthesis of 3-fluoro-GABA enantiomers. This was achieved from L- and D- phenylalanine in six steps and in an overall yield of 31%. The preferred conformations of 3-fluoro-GABA in solution are then explored by NMR analysis and ab initio calculations. The biological evaluation …
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The separation of specific enantiomers of anticancer reagent cytarabine using HPLC.
… need to investigate the properties of existing enantiomers, if the drug possesses chirality. It is becoming increasingly more of a requirement to separate specific enantiomers in order to optimize the potency and reduce the toxicity of certain drugs. Consequently, there is a huge interest in …
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Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods
… autoimmune, inflammatory, and cancer conditions. Enantiomers of the lignan zuonin A, (-)-zuonin A and (+)-zuonin A, have been shown to bind to JNK isoforms with similar affinity and disrupt protein-protein interactions at JNK's D-recruitment site, making them a good candidate for specific non-ATP …
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Factors affecting the disposition of the enantiomers of arylpropionic acids: focus on flurbiprofen
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Direct High Pressure Liquid-Chromatographic Separation of Enantiomers Using a Chiral Stationary Phase
Made available in DSpace on 2014-12-13T20:10:32Z (GMT). No. of bitstreams: 1 7913489.pdf: 4055959 bytes, checksum: 1b59cd26023407fa8f92d0edc55d48a3 (MD5) Previous issue date: 1978
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ASSESSING THE EFFECTS OF KETAMINE AND ITS ENANTIOMERS ON COMPULSIVE-LIKE AND DEPRESSIVE-LIKE BEHAVIOR
<p>Obsessive-compulsive disorder (OCD) is a common and often serious disorder that can impair a person’s ability to function and live a normal life. The current first line treatments for OCD are serotonin reuptake inhibitors (SRIs), cognitive behavioral therapy (CBT), or a combination of these …
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Direct Liquid Chromatographic Separation of Enantiomers of Phthalides, Phthalimidines and Related Compounds on Chiral Stationary Phases
The enantiomers of a diverse series of 3-arylphthalides are separable by high performance liquid chromatography on chiral stationary phases (CSPs) derived from the N-3,5-dinitrobenzamides of (S)-leucine or (R)-phenylglycine covalently bonded to aminopropyl silanized silica. A chiral recognition …
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Type II Estrogen Binding-Site Agonist: The Synthesis and Biological Evaluation of the Enantiomers of Methyl-Para-Hydroxyphenyllactate (MeHPLA)
… associated cellular activity. In this study, the enantiomers of MeHPLA were synthesized and separated by three methods. The methods included the use of the enantioselective catalyst, oxazoborolidine, the enzyme, lactate dehydrogenase, and the diastereomeric separation using a chiral amine. When …
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Chromatographic Separation of Enantiomers of Some Physiologically Active Types of Compounds on Chiral Stationary Phases (Benzodiazepinones, Beta-Lactams, Beta-Aminoacids)
The enantiomers of some important types of compounds have been separated by chromatography on chiral stationary phases. Thus benzodiazepinone enantiomers and enantiomers of aryl substituted (beta)-lactams can be separated directly on amino acid derived chiral stationary phases, whereas (beta)-amino …
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The interactions of Propafenone and its enantiomers with the major human forms of cytochrome P450 in terms of inhibition and metabolic rates
… forms of the drug can exist. Propafenone enantiomers have been shown to have similar pharmacological properties, but studies are limited with regards to their disposition and interaction with drug metabolising enzymes. The aim of the study conducted here was to investigate the interaction …
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Enantioselective Adsorption of 1,3-Dithiolane-1-Oxides and Related Compounds on Liquid Chromatographic Amino Acid-Derived Chiral Stationary Phases (Resolution, Enantiomers, Sulfoxides)
… liquid chromatographic separation of the enantiomers of 1,3-dithiolane-1-oxides and related compounds. The structure-enantioselectivity relationships allow determination of two fundamental chiral recognition models for resolution of enantiomeric analytes which, in turn, allow assignment of …
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Nmr Spectroscopy of Enantiomers in Chiral Solvents: The Relationship Between Solvate Physical Properties and Enantiomeric Spectral Nonequivalence in Model Amine - Alcohol Systems
Made available in DSpace on 2014-12-09T17:36:51Z (GMT). No. of bitstreams: 1 7105061.pdf: 3588128 bytes, checksum: 612c5abb7a0be26878eb367701a9deb1 (MD5) Previous issue date: 1970
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Asymmetric Positron Annihilation in Chiral Tartrate and Tartaric Acid Crystals
… between large crystals grown from the D- and L- enantiomers of sodium ammonium tartrate and tartaric acid. A tentative but statistical difference in and I2 between enantiomers is noted with the L- enantiomers exhibiting longer positronium lifetimes and lower intensities, signifying a more stable …
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Side Chain Functionalized Hexestrols and Norhexestrols as Probes for the Estrogen Receptor
… have been synthesized and resolved into pure enantiomers. Binding studies with lamb uterine estrogen receptor indicate that there is no appreciable difference in binding between enantiomers in the hexestrol series while enantiomers in the norhexestrol series do show significant differences in …
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Investigations of molecular recognition processes
… stationary phases (CSPs) for the separation of enantiomers is commonplace. A variety of $\alpha$-alkyl and $\alpha$-aryl substituted $\alpha$-amino phosphonates were prepared. The ability of several CSPs to separate the enantiomers of N-(3,5-dinitrobenzoyl) derivatives of $\alpha$-alkyl and …
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Design, Synthesis, and Applications of Chiral Stationary Phases
… direct liquid chromatographic separation of the enantiomers upon a chiral stationary phase. The aim of this research was to develop efficient and widely useful chiral stationary phases. Our approach to this problem was to synthesize a series of specific chiral compounds containing three sites for …
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