Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Enabling Formulations"”.
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
… technique in the production of oral solid dosage formulations, its operating capacity has the capability to address formulation and manufacturing issues associated with drugs which possess poor solubility, permeability and bioavailability. With traditional, batch-style manufacturing methods …
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Computational pharmaceutics approaches to inform drug developability: focus on lipid-based formulations
… tools which assess the delivery potential of bio-enabling formulations. However, there is a perceived risk associated with early-stage selection of bio-enabling formulations. Computational pharmaceutics is a growing area of research interest to support structured guidance in formulation strategy. …
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Solid Dispersions in Medium-Insoluble Hydrogels for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Formulating poorly water-soluble drugs into Amorphous Solid Dispersions (ASDs) based on medium-insoluble hydrogels is an emerging approach showing promise for tackling solubility related oral bioavailability problems. However, critical parameters important to the design of these ASDs have not been …
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Investigation of Pharmaceutical Mass Transfer Phenomena Using Molecular Dynamics Simulations
… of polymers in designing supersaturation-based enabling formulations.</p>
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The development of preclinical strategies for facilitation of lead candidate selection
… and acid liability. Therefore, two solubility enabling formulations were created and tested for <em>in vitro</em> permeability and <em>in vivo </em>murine pharmacokinetics. (Abstract shortened by ProQuest.)</p>