Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1860 for “"Embryonic"”.
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Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro
… mammalian development to term requires that embryonic and extra-embryonic tissues communicate and grow in coordination, to form the body. After implanting into the uterus, the mouse embryo is comprised of three cell lineages: first, the embryonic epiblast (EPI) that forms the embryo proper, …
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Molecular Basis of Vertebrate Embryonic Migration
<p>Embryology aims at understanding how a single fertilized cell develops into a complex multicellular organism. Initially the embryo is no more than a ball of cells where the three primordial layers, the ectoderm, mesoderm and the endoderm are one on top of the other. The three germ layers will go …
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CBD & Ethanol Disrupt Early Embryonic Development
… Zebrafish, a viable translational model for embryonic and neural development, is a cost-effective and translational model that has previously been used in drug research. In the present study, zebrafish embryos were chronically exposed to CBD for 10 days. Embryonic development was assessed at …
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Mesoderm diversification during mouse embryonic development
During early mouse embryonic development, a single cell, the fertilised egg, will give rise to a wide range of cell types that become specialised at a functional and molecular level. Gastrulation and early organogenesis are two of the most critical events during these early stages, when pluripotent …
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Liver Cell Adhesion Molecules in Embryonic Development
<p>Cell-cell adhesion is one of the essential processes for normal embryogenesis. The isolation and characterization of the neural cell adhesion molecule, N-CAM, provided the first substantial opportunity to study this process at a molecular level. Moreover, studies of N-CAM expression in embryos …
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Dynamics and Mechanics of Zebrafish Embryonic Tissues
… mechanical and dynamical properties of zebrafish embryonic cells and tissues. This thesis is structured as follows: In chapter 2, we introduce the fundamental concepts that are important for the study of cell motion during zebrafish embryonic development. In chapter 3, the materials and methods …
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Human embryonic stem cells for genotoxicity testing
… limits use of primary explanted cells. Human embryonic stem cells (hESCs) have been validated as a stable and healthy human cell source. This study aimed to investigate the utility of hESCs as a cellular model for genotoxicity testing. Chromosomal analysis by PNA-FISH and mFISH following …
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H4K16 acetylation during embryonic stem cell differentiation
… MOF in mice leads to mass chromatin defects, and embryonic lethality prior to the blastocyst stage. I set out to understand the role of H4K16ac in differentiating Embryonic Stem cells (ES cells) and chromatin compaction in vivo. I generated a ChIP-seq profile for H4K16ac in undifferentiated ES …
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Nuclear Transfer With Porcine Embryonic Stem Cells
Results from embryo culture experiments indicated: (1) bovine serum albumin (BSA) supplementation improved developmental rates of four- and eight-cell Meishan embryos to the blastocyst stage, (2) fetal bovine serum supplementation improved hatching rates of later stage Meishan embryos, (3) fatty …
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Dazl regulates mouse embryonic germ cell development
… initiation of meiosis in female, but not male, embryonic germ cells. Experiments were performed showing that germ cells of both sexes transit through a state, the meiosis competent germ cell, that is required for initiation of meiosis. Acquisition of this state requires the function of the germ …
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Molecular control of embryonic stem cell identity
Embryonic Stem (ES) cells are the in vitro derivatives of the inner cell mass of a developing embryo, and exhibit the property of pluripotency, which is the ability of a cell to give rise to all cell lineages of an organism. Therefore, these cells hold great promise in the treatment of several …
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Studies on the Differentiation of the Golgi Apparatus in Nerve Cells of the Chick During Embryonic and Post-Embryonic Development
Made available in DSpace on 2014-12-04T22:46:18Z (GMT). No. of bitstreams: 1 6402854.pdf: 4400791 bytes, checksum: 4298d2cdd9ff59b2f3550bfbadfe5242 (MD5) Previous issue date: 1963
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Mitochondrial DNA replication in pre-implantation embryonic development
… in oocytes, pre-implantation embryos and embryonic stem cells (ESCs) and that this may be disrupted following nuclear transfer (NT). MtDNA copy number decreased between 2-cell and 8-cell staged porcine embryos and increased between the morula and expanded blastocyst stages, coinciding with …
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Factors Influencing Early Embryonic Development in the Pig
… higher levels of these phytoestrogens affect embryonic development.
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Tumor-like growth of mouse embryonic stem cells
… capability of self-renewal and differentiation, embryonic stem cells (ESCs) are an invaluable tool for research in regenerative medicine. However, the main problem that hampers application of ESCs to practical stem cell therapies is that ESCs can grow as tumors when transplanted. To date, only …
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Understanding the Dynamics of Embryonic Stem Cell Differentiation
The two defining features of mouse embryonic stem (ES) cells are self-renewal and naive pluripotency, the ability to give rise to all cell lineages in the adult body. In addition to being a unique and interesting cell type, pluripotent ES cells have demonstrated their potential for continued …
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Programming of the paternal nucleus for embryonic development
… However, it is known that sperm supports embryonic development better than other cell types, suggesting that it might also have additional important, non-genetic contributions to embryonic development. The work described in this dissertation focuses on identifying the molecular …
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Characterization of the cardiogenesis of embryonic stem cells
… can affect the cardiogenesis process of embryonic stem cells. First, a compliant microfluidic system was developed to study the individual and combined effects of culture dimensions and uniaxial cyclic stretch on the differentiation process. A smaller culture dimension, with a …
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