Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Emax model"”.
-
Sample size determination for Emax model, equivalence / non-inferiority test and drug combination in fixed dose trials.
… economic and human resources, but also improve model performance and efficiency. We first explore the sample sizes of Emax model for a simple one group crossover design. Emax model is the one of the most frequently used models defining the relationship of drug efficacy with respect to its dosing …
-
Pharmacokinectic and pharmacodynamic aspects of cocaine and its interaction with ethanol
… physiologically based-pharmacokinetics modeling; the influence of ethanol on cocaine disposition. Further, cocaine and cocaethylene (CE) were compared using pharmacokinetic-pharmacodynamic (PK-PD) models. Lastly, PK-PD models after cocaine and a combination of cocaine and ethanol dose …
-
Pharmacokinetic and Pharmacodynamic Modelling to Advance Perioperative Anaesthesia and Analgesia
… Pharmacokinetic (PK) and pharmacodynamic (PD) models summarise complex drug relationships so they may be better understood and capitalised on. I report my investigations into using PKPD models to describe combined drug responses for applications in anaesthesia. I investigated analgesia in …
-
Paediatric Dexmedetomidine Pharmacology
… were estimated using non-linear mixed effects models. Parameter estimates for a two-compartment model were: clearance (CL) 39.2 (30.4%) L.h-1.70kg-1, central volume of distribution (V1) 36.9 (69.5%) L.70kg-1, intercompartment clearance (Q) 68.2 (37.6%) L.h-1.70kg-1, and peripheral volume of …
-
A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies
… developed a Bayesian framework for dose-response modeling and drug-drug interaction analysis. First, we developed a hierarchical meta-regression dose-response model that accounts for various sources of variation and uncertainty and allows one to incorporate knowledge from prior studies into the …