Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Elongation Factor Tu."”.
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Evaluation of five bifidobacterium isolates as potential probiotics and genetic analysis of their ability to withstand oxidative stress
… region, the heat shock protein (hsp60) and Elongation factor Tu (tuf).
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Processes involved in protein translation
… synthases; and the ribosome and its various elongation, initiation, and release factors—to carry out the translation process. It is the latter group, ribosomes and associated proteins, that physically make the peptide chains. In the following thesis, we will explore the assembly and function …
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Investigating the mechanisms of protein synthesis using multi-resolution structural data
… at ever increasing resolution. In order to study different aspects of ribosome function at the atomic level, we developed the molecular dynamics flexible fitting (MDFF) method that combines X-ray and cryo-EM data, furnishing atomic models of the ribosome corresponding to functional …
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Characterisation of potential regulators of PAMP-triggered immunity
… PRRs, which recognise the bacterial elongation factor Tu and flagellin, respectively. A variety of downstream responses upon PAMP perception have been described. However, it is still poorly understood how EFR- and FLS2-dependent signalling is mediated. Here, I used two different …
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The Development and Application of Methods to Study the Evolution of Specificity, Allostery, and RNA -Protein Interactions in Translation
… several archaea that eluded previous annotation studies. This enzyme was found to be involved in the indirect pathway of cysteine aminoacylation that is shown to exist in the last universal common ancestral state. We have developed a network analysis based on molecular dynamics simulations in …
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The characterisation of the cell surface of Staphylococcus aureus in the search for new therapeutic targets
… the data in light of our surface proteome studies. This approach enabled us to gain insight into novel binding characteristics used by surface-accessible proteins that could not be predicted using reverse vaccinology and other hypothesis-directed approaches commonly used to develop potential …
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Simulation and visualization of dynamics in RNA-protein complexes in translation
… tools were developed during the course of this study. We present the evolutionary analysis environment MultiSeq, dynamical network analysis and visualization, and a protocol for the preparation of RNA·protein MD simulations. For several Class I aminoacyl-tRNA synthetases (aaRSs), the rate …
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Identification of tumour-associated gycoproteins recognised by the lectin from Helix pomatia in breast cancer
… as targets for immunotherapy. Previous studies have shown that HPA recognises a multitude of proteins in colorectal cancer (CRC). This study aimed to establish whether HPA recognises the same glycoproteins in breast cancer. An in vitro model of human breast cancer cell lines was used, …
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Evolution and dynamic behavior of transfer RNA in the first two steps of translation
… tRNAs dissociate from the aaRSs and bind the elongation factor Tu (EF-Tu) for delivery to the ribosome. The recognition of specific tRNA species by the aaRSs, EF-Tu, and other enzymes along the translation pathway is based on sets of highly conserved nucleotides within different groups of tRNA …
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Analysis of protein-protein interactions linked to the formation of a bacterial cytoskeleton in Mycoplasma pneumoniae
… pneumoniae has a cytoskeleton-like structure. Based on genetic evidence, it was proposed that the 1818 amino acids long protein HMW2 plays a central role in both formation of the cytoskeleton-like structure and adherence to its host cell (cytadherence). As gene products of the hmw2 gene …