Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Ellipticine"”.
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Synthesis and evaluation of novel ellipticines as potential anti-cancer agents
Ellipticine is a natural product which possesses multimodal anti-cancer activity. This thesis encompasses the synthesis and biological evaluation of novel ellipticine and isoellipticine derivatives as anti-cancer agents. Expanding on previous work within the group utilising vinylmagnesium bromide, …
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Crystallization of active pharmaceutical ingredients using microfluidic platforms and meniscus-guided coating
… reported crystal structure for aspirin. Films of ellipticine, a model drug, were found to also display multiple morphologies, and again the molecular packing of the different morphologies was the same. However, the ellipticine films did not match the reported crystal structure, the films pack in a …
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Synthesis of o-isotoluenes, o-quinodimethanes, and benzoenynyl carbodiimides and their cyclizations to polycyclic and heterocyclic compounds
… for preparation of the 5-aza anologues of ellipticine, a naturally occuring alkaloid having potent anti-cancer properties. This approach, which constructs the B and the C rings in one step, is an efficient route in producing the aza analogues of the ellipticine family of antitumor alkaloids.
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Effect of Comorbidities on HIV-1 Pathogenesis in Monocytic Cells
… such as resveratrol, CYP1A1 inhibitor (ellipticine) and CYP2A6 inhibitor (Tryptamine) including chemodietary agents such as curcumin (20 μM) and curcubitacin-D (0.1 μM), significantly reduced the CCS and CCS-Exo mediated HIV-1 replication in U1 cells. These results suggest the role of …
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Mechanismus působení protinádorového léčiva ellipticinu v cílových tkáních jeho účinku
… Z výsledků vyplývá, že u zvířat premedikovaných ellipticinem dochází k zvýšení exprese i katalytické aktivity CYP podrodiny 1A ve všech testovaných orgánech (játra, ledviny, plíce). V játrech navíc dochází vlivem ellipticinu ke zvýšení exprese cytochromu b5 a zvýšení exprese a katalytické …