Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Electrospray ionisation mass spectrometry"”.
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An investigation of beryllium coordination chemistry using electrospray ionisation mass spectrometry
The electrospray ionisation mass spectrometric behaviour of various complexes of beryllium have been investigated in this thesis. These beryllium complexes were prepared in situ on a small scale by preparing appropriate molar mixtures of the Be²⁺ ion with ligands in a range of solvent systems. In …
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The use of model compounds to investigate the influence of fuel composition on the thermo-oxidative stability of fame/diesel blends
… was performed using gas chromatography (GC) with mass spectrometric (MS) and flame ionisation (FID) detection. Further analytical methods included Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy as well as electrospray ionisation-mass spectrometry (ESI-MS).
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A quantitative characterisation of phospholipid composition and biosynthesis in HeLa cells and nuclei - a mass spectrometry study
… as transcription. This study utilised tandem electrospray ionisation mass spectrometry to determine, quantitatively, the phospholipid content of cultured HeLa (Human cervical carcinoma) cells and their isolated naked nuclei. Endonuclear PC, DAG and PI was found to be enriched in disaturated …
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The Development of High Accuracy Methods for the Measurement of Metal Speciation
… for performing species-specific isotope dilution mass spectrometry (ssIDMS) analysis of a protein. A ®^Cu enriched copper binding Rc spike was prepared from Rc produced using a bacterial recombinant system. The stability of the ®^Cu binding spike was investigated using both inductively coupled …
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Biosynthesis and characterisation of polyhydroxyalkanoate biopolymers and their oligomers for circular economy
… from the [text redacted] starting material. Electrospray ionisation mass spectrometry (ESI-MS) confirmed the monomer composition of the polymer produced with LDPE and PE-T to be 3-hydroxybutyrate, 3-hydroxyvalerate and 3-hydroxyhexanoate and that with [text redacted] to be 3-hydroxybutyrate …
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Sviluppo di tecniche di analisi ifenate per la quantificazione di biomarcatori di esposizione a tossici ambientali: gli acidi mercapturici
… analysed with a liquid chromatography coupled to electrospray ionisation-mass spectrometry (μHPLC-ESI-MS/MS) method for the simultaneous quantitative detection of the BTX exposure biomarker SPMA, SBMA and o-MBMA in human urine. Urinary S-phenylmercapturic acid (SPMA) is a biomarker proposed by the …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
… (n=7)) by liquid chromatography coupled with electrospray ionisation mass spectrometry (LC/ESIMS/ MS). Cytokines produced by CVF collected from pregnant donors (20-41 weeks gestation, n=2-10) were investigated using Enzyme-Linked Immunosorbent Assay (ELISA) or Luminex®. Human endometrium …
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Development of copper peptide complexes as anti-Inflammatory drugs
… (Uv-Vis), nuclear magnetic resonance (NMR), electrospray ionisation mass spectrometry (ESI-MS) spectroscopy as well as molecular mechanics (MM) calculations. The visible spectra obtained for the different species in solution were typical of Cu(II) and Ni(II) complexes. 1H NMR identified the …
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The identification of prostate cancer associated tumour antigens and biomarkers
… by conventional proteomic methods (2-DE and mass spectrometry) with serological screening using serum antibodies, to identify immunogenic proteins in cancer. This project aims to identify TAAs and/or biomarkers for PCa which on subsequent validation, can be utilised as an improved diagnostic …
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The application of capillary electrophoresis and mass spectrometry to clinical and environmental problems
… were analysed using a combination of CE alone, mass spectrometry alone and also coupled capillary electrophoresis/electrospray mass spectrometry (CE/ES). Clinically orientated analytes, dipeptides in urine and acylcamitines from blood spots were examined and peaks detected directly via uv …
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Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
… dissociation experiments were carried out using electrospray ionisation mass spectrometry on gas phase complexes involving different poly(methylmetacrylate) oligomers with three amino acids: glycine, leucine, and phenylalanine. After acquiring breakdown diagrams, RRKM modeling was used to fit the …
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Electrospray mass spectrometric analysis of transition metal carbonyl clusters
A key objective of this thesis was to develop Electrospray (Ionisation) Mass Spectrometry (ESMS) within organometallic chemistry, specifically as a technique for investigating transition metal carbonyl cluster chemistry. An initial survey of air-sensitive high-nuclearity rhodium and nickel …
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Naphthenic Acids: Synthesis, Characterisation and Factors Influendng Environmental Fate
… The metabolites were tentatively identified by mass spectrometry as the ethanoic acid analogues of the butanoic acids. These resisted further biodegradation. That biodegradation proceeded via β-oxidation was confirmed by the synthesis and subsequent biodegradation additional methyl branch in the …
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Design, Synthesis and Catalytic Evaluation of Mono- and Polynuclear Organometallic Materials as Hydroformylation Catalysts
… 13C{1H} NMR spectroscopy, IR spectroscopy and electrospray ionisation mass spectrometry. The complexes were successfully evaluated as catalyst precursors in the hydroformylation of 1-octene. The reaction conditions were optimised at 75 ℃, 40 bar syngas pressure for 4 h with 2.87 x 10-3 mmol …
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The development of group VIII trinuclear transition metal complexes as chemotherapeutic and photodynamic therapy agents
… Infrared (IR) spectroscopy and high-resolution electrospray ionisation mass spectrometry. These complexes comprised of either the trisamine or the s-triazine core/ central functionality to probe the effects of the aforementioned central moieties on the applicability of the complexes as …
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ESIMS targeted synthesis of novel {Pt2S2} derivatives
Electrospray ionisation mass spectrometry (ESIMS) was used to investigate ring- opening reactions of several epoxides with the nucleophilic dinuclear PtII complexes [Pt2(μ-E)2(PPh3)4] (E = S, 1a; Se, 1b) and several activated cyclopropanes, N - tosylaziridine, and thiirane with 1a. Epoxides …
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Development of aminoquinoline-benzimidazole hybrids and their organometallic complexes as antimicrobial agents against Plasmodium falciparum and Mycobacterium tuberculosis
… and HSQC NMR spectroscopy, IR spectroscopy and electrospray ionisation mass spectrometry. The organic and ferrocenyl aminoquinoline-benzimidazole hybrids were screened in vitro against the chloroquine-sensitive (CQS) NF54 strain and multidrug-resistant (MDR) K1 strain of P. falciparum. Most …
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Electrically Polarised Electrodes in DMSO and DMF electrolytes of Pseudohalide Salts: In situ IR studies supported by EXAFS/XANES and other techniques
… X-ray absorption spectroscopy (XAS). Further electrospray ionisation mass spectrometry (ESI-MS) was also used to confirm the presence of such species and to characterize other by-products formed in the model solutions. In general, the data showed that the nickel electrode undergoes …