Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Electroretinogram (ERG)"”.
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Mechanisms of pH regulation and the generation of the electroretinogramb-wave in the toad retina
… responses of rods and Muller cells, and the electroretinogram (ERG), have been studied under various conditions.
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Generation of the electroretinogram M-wave and PII components in the amphibian retina
The electroretinogram (ERG) is a field potential generated by the electrical activity of the retina in response to a flash of light. The ERG is measured in humans and is useful in the diagnosis of retinal pathologies. The investigations reported in this thesis were undertaken with the expectation …
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Modeling of phototransduction in vision systems
To improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics in the phototransduction cascade and experimental data. A set of …
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Retinale Ischämie bei der intraluminalen Fadenokklusionsmethode
… changes were showed by the recording of the electroretinogram (ERG), using cresyl-violet staining and by immunhistochemical staining of astroglial, microglial, cytokin and apoptotic markers. The ERG showed a suppression of the a- and b-wave with only a recovery of 50% of the b-wave amplitude …
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Spectral Sensitivity of the Goldfish ERG and Optic Tectum Before and After Optic Nerve Damage
… increment threshold procedure was used to obtain electroretinogram (ERG) and tectal responses to light onset and termination to various wavelengths of light. Spectral sensitivity functions were derived from both the ON- and OFF-components at both visual levels. By examining the spectral …
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The use of Silent Substitution in measuring isolated cone- and rod- Human ERGs
After over a decade of its discovery, the Electroretinogram (ERG) still remains the objective tool that is conventionally used in assessment of retinal function in health and disease. Although there is ongoing research in developing ERG recording techniques, interpretation and clinical …
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The use of silent substitution in measuring isolated cone- & rod- human electroretinograms. An electrophysiological study of human rod- and cone- photoreceptor activity derived using silent substitution paradigm
After over a decade of its discovery, the Electroretinogram (ERG) still remains the objective tool that is conventionally used in assessment of retinal function in health and disease. Although there is ongoing research in developing ERG- recording techniques, interpretation and clinical …
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Effects of Restricted Spectral Rearing on the Development of Zebrafish Retinal Physiology
… of retinal physiology was done by using the electroretinogram (ERG). The results showed that restricted spectral rearing caused differences in zebrafish retinal physiology. Rearing larvae in any of the constant light conditions caused deficits in sensitivity to ultraviolet and …
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The Isolation of Human Rod and Cone Photoreceptor Activity combining Electroretinography and Silent Substitution Techniques
Aims: The electroretinogram (ERG) can be used to independently assess the function of rod and cone photoreceptors within the human retina. The work in this thesis sought to investigate an alternative method of recording the ERG, using the silent substitution paradigm (Estevez and Spekreijse 1982). …
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The Effect of Gonadotropin Releasing Hormone on Opsin Gene Expression and Spectral Sensitivity in Zebra Cichlid Fish (Metriaclima zebra).
… implants and intubation was investigated using electroretinogram (ERG) recordings, quantitative real-time RT-PCR and in situ hybridization. Three week and ten week sampling periods were used in the intubation study. No obvious differences in spectral sensitivity were evident when looking at …
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Determination of Chromatic and Luminance Channels in the Zebrafish Visual System Using an Increment Threshold Technique
… increment threshold procedure was used to elicit electroretinogram (ERG) b-wave responses to monochromatic light under two different intensities of white background adaptation. From the ERG b-wave responses, a spectral sensitivity function was derived under low and high levels of white background. …
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Characterization of Retinal Defects in Engrailed-2 Knockout (En2-/-) Mice, a Model for Autism Spectrum Disorders (ASD)
… 2007), and a significant loss of forebrain GABAergic interneurons (SgadÃ2 P et al., 2013). En2-/- mice also display autistic-like behavioral defects, including decreased sociability (Brielmaier J, et al., 2012), enhanced seizure susceptibility (Tripathi P P, et al., 2009) and impaired spatial …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
… AMD and were employed in the current study. The electroretinogram (ERG) demonstrated that photoreceptoral and postphotorecetoral functions involving both rod and cone pathways were dramatically reduced following light damage (LD) compared to normal non-LD rat eyes. Microglia activation and …
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Analysis of Zebrafish Optic Tectum Visual Processing Before and After Optic Nerve Crush
… adult zebrafish and to compare them to previous electroretinogram (ERG) spectral sensitivity data (Bilotta & Harrison, 1999). The second purpose of this study was to examine neural regeneration in the adult zebrafish at various times post-crush and to compare visual processing of these subjects …
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Zebrafish Retinal Development and the Effects of Abnormal Light Rearing Conditions
… method used to assess retinal function was the electroretinogram (ERG). Comparisons were made across the three age groups and the three conditions. Differences in the ERG waveforms and spectral sensitivities across the three ages were found. The 6-8 and 13-15 dpf subjects were less sensitive …
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THE ROLE OF R7 REGULATORS OF G PROTEIN SIGNALING IN THE RETINA
… viable and fertile, but have a small body size. Electroretinogram (ERG) b-wave implicit time in young RGS7-/- mice is prolonged at eye opening, but the phenotype disappears by 2 months of age. Expression levels of RGS6 and RGS11 are unchanged in RGS7-/- retina, but the Gβ5S level is significantly …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic …
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A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
… retina with healthy cells to improve vision. Emerging therapies, in clinical trials, are investigating stem cell-derived photoreceptors injected, in a saline solution, into the subretinal space to replace dying cells caused by retinal degeneration. The principal objectives of this thesis were to …