Global ETD Search
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Showing 1 to 15 of 15 for “"Electric pulses"”.
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Time-dependence of ionization and excitation by intense, short electric pulses
In this thesis studies of time-dependent electric pulse ionization and excitation of atomic systems (the hydrogen atom and its negative ion) are performed. Unidirectional (half-cycle) pulses are considered, as well as oscillating (up to several-cycle) pulses. The time scale of the pulses considered …
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Asymmetrical transmembrane potential in intracellular organelles of adrenal chromaffin cells exposed to nanosecond electric pulses
… on exploring the effects of 5 ns, high intensity electric pulses on neurosecretory adrenal chromaffin cells, cell modeling has played an important role in understanding and explaining the experimental results. Externally applied nanosecond-duration electric pulses (NEPs) can affect cells by …
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Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses
<p>The effects of high-voltage nanosecond electric pulses (nsEPs) on metastatic melanoma are still unclear. Hence, we applied one, two, three, and four 300 ns 40 kV/cm pulses to murine B16-F10 melanoma cells. Cell attachment ability was determined by comparing the number of floating cells and the …
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Characterizing the Movement of Contaminant Liquid Metal Particles when subject to Electric Pulses, within the Context of Z-pinch Fusion Reactors
… a eutectic tin-bismuth mixture to high-current pulses. Particle motion was tracked and analyzed using high-speed camera footage processed with advanced techniques, including contrast limited adaptive histogram equalization (CLAHE), neutral-density filtering, and Sobel edge detection. The …
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5 ns Electric pulses evoke longer-lived calcium responses in adrenal chromaffin cells than the physiological stimulus: an experimental and computational study
Nanosecond duration electric pulses of high electric field magnitudes (>1 MV/m) are being explored by our group as a novel type of electric stimulus for evoking catecholamine release from neuroendocrine adrenal chromaffin cells. The overall goal of this work is to understand why 5 ns, 5 MV/m pulses …
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Irreversible Electroporation Therapy for the Treatment of Spontaneous Tumors in Cancer Patients
… in a targeted volume of tissue, using brief electric pulses, (~100 µs long) delivered through electrodes placed into or around the targeted region. These electric pulses destabilize the integrity of the cell membrane, resulting in the creation of nanoscale defects that increase a cell’s …
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Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma
… tissue ablation technique that uses low-energy electric pulses to destabilize cell membranes, thus achieving tissue death. The procedure is minimally invasive and is performed through small electrodes inserted into the tissue with treatment duration of about one minute. The pulses create an …
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Cycled Pulsing for Prostate Tumor to Mitigate Thermal Damage, While Conserving the Ablation Area
… is a minimally thermal technique which delivers electric pulses to create transient nanopores in cell membrane, ultimately leading to cell death. IRE is predominantly non-thermal technique, but the thermal side effect of Joule heating exists during treatment. Cycled pulsing of IRE is a technique …
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Pulsed MOSFET based linear transformer driver
… the generation of intense and short bursts of electric pulses to generate high energy X-rays to inspect dense objects. The generation of fast transition, short width, repetitive pulses for effective output requires switching technology which has limitations. From the traditional slow switching …
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A unified model of electroporation and molecular transport
… termed electroporation. These pores facilitate electrical and molecular transport across cell membranes that are normally impermeable. By applying pulsed electric fields to cells, electroporation can be used to deliver nucleic acids, drugs, and other molecules into cells, making it a powerful …
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New Tools for Real-Time Study of Embryonic Development
… and spectroscopy (DFOMS), and ultrashort electric pulses. We have designed and synthesized a mini-library of Au and Ag NPs with different sizes and chemical properties. We have used developing zebrafish embryos as <em>in vivo</em>model organisms to study embryonic development and as <em>in …
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Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
… Electroporation (H-FIRE), which utilizes electric pulses to ablate tumor cells, affect the lymphatic and blood microvasculature in the tumor, surrounding fat pad, tumor draining lymph node (TDLN) using multiple analysis methods. This occurred through three main methods 1) identification of …
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Flow-Through Electroporation in Asymmetric Curving Microfluidic Channels
… area makes it possible to produce electric pulses of various parameters by using a dc power supply. We successfully delivered Enhanced Green Fluorescent Protein, EGFP, plasmid DNA into Chinese Hamster Ovary, CHO-K1, cells in our microfluidic chips. We show that the particles/cells …
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Tissue Engineered Scaffolds and Three Dimensional Tumor Constructs to Evaluate Pulsed Electric Field Treatments
… ablation therapy. IRE uses short, high-intensity electric pulses to create pores in a cell's membrane and disrupt its stability. At a certain energy level, damage to the cell becomes too great and it leads to cell death. The particular mechanisms that drive this response are still not completely …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
… due to altered cell and tissue mechanics. Pulse electric field (PEFs), which employ intense external electric fields to cause electroporation, a phenomenon characterized by increased cell membrane permeability, also can cause significant changes to cell and tissue mechanics. Here, we investigate …