Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Elastin-like polypeptide"”.
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Leukocyte Response to Elastin-Like Polypeptide Coatings
… thrombosis. The extracellular matrix protein elastin has been found to be one of the least thrombogenic components of blood vessels, and its purified and recombinant forms have shown reduced thrombogenicity in both in vitro and in vivo models. Biomaterial coatings of elastin-like polypeptides …
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Understanding Elastin-Like Polypeptide Block Copolymer Self-assembly Behavior
<p>Elastin-like polypeptides (ELPs) are thermally responsive polymers composed of the pentapeptide repeat Valine-Proline-Glycine-X-Glycine where X is any amino acid except proline. ELP diblocks have been engineered by creating two ELP blocks with hydrophilic and hydrophobic guest residues. The …
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Elastin-like polypeptide (ELP) tags for self-assembly and high-throughput processing of functional protein materials
… bioconjugate materials with a genetically fused elastin-like polypeptide (ELP) tag. The first part of this thesis explores the effects of ELP charge and hydrophobicity on the self-assembly of ELP-mCherry fusion proteins in concentrated solution.
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Beak and feather disease virus candidate vaccine development
… benthamiana) was optimised as fusions to elastin-like polypeptide (ELP). Fusion of CP or ÄN40 CP to ELPs of different lengths was shown to increase yield relative to unfused CP/ÄN40 CP. Free ELP and a GFP-ELP fusion could be purified by inverse transition cycling (ITC), using …
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Biologically Inspired Design of Protein-Silica Hybrid Nanoparticles for Drug Delivery Applications
… this system is catalyzed by self-assembled elastin-like polypeptide (ELP) micelles that incorporate of a class of biologically-inspired, silica-promoting peptides, silaffins. Furthermore, this methodology produces near-monodisperse, hybrid inorganic/micellar materials under mild reaction …
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Expression, Purification, And Characterization Of Elastin-Like Polypeptides Containing Chondroitin Sulphate Binding Domains
… a small-diameter blood vessel. Using recombinant elastin-like polypeptides (ELPs) developed by the Woodhouse laboratory, as well as chondroitin sulphate-specific binding sequences (CSBD1 and CSBD2) determined by the Panitch laboratory, a new elastin-like polypeptide-chondroitin sulphate binding …
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Assembly of Highly Asymmetric Genetically-Encoded Amphiphiles for Thermally Targeted Delivery of Therapeutics
… is to exploit a class of recombinant chimeric polypeptides (CPs) to actively target drugs to tumors as conjugation to macromolecular carriers has demonstrated improved efficacy by increasing plasma retention time, reducing uptake by healthy tissues, and enhancing tumor accumulation by …
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Structure-property relationships in physical polymer gels
… These systems are comprised of thermoresponsive elastin-like polypeptide endblocks (ELPs) fused to a polypeptide containing self-associating a-helical domains. Above the critical gel concentration, these protein fusions form disordered spherical nanostructures in solution. In shear flow, the rate …
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Bioorthogonal Functionalization of Elastin-like Polypeptides
… and non-canonical R-groups directly into the polypeptide backbone of a protein or biopolymer. These residues introduce unique chemical reactivity for further functionalization with desired moieties or chemical transformation. </p><p>We have used this technology to develop novel therapeutic and …